Heavy water labeling of leukocytes in human skin and vet and additional cell populations in fat such as macrophages and adipocytes

Recruiting

• Conditions: immunological defense in the skin; skin immunity; 10047954; 10027665; 10014982

• Registration Number: NL-OMON56368
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 35

Inclusion Criteria

Excessive skin removal (body contouring, abdominoplasty), breast reduction
surgery

Exclusion Criteria

Skin disease, chonische infectious disease, daily use immuno modulatory drugs

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p> Production and loss rates ( lifespans) of different leukocyte subpopulations<br /><br>derived from healthy skin, fat and blood. Additional production and loss rates<br /><br>of different cell populations such as adipocytes and macrophages in fat.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Fraction of skin cells replaced by circulating blood leukocytes </p><br>