Deuterated water labelling of specialized T cell subsets

Conditions: immunological memory
10027665
Healthy immune system

Registration Number: NL-OMON56738

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 26

Inclusion Criteria

For study group I
To be eligible for inclusion in study group I cohort of this study, a subject
must meet all of the following criteria:
Participants
- Are healthy
- Have vaccination history with either TWINRIX, MMR or IPV and being
seropositive for one of the vaccines.
- Are above the age of 18
- Are able to understand a written informed consent form
- Are able to follow the protocol of the study during the study period

For study group II
To be eligible for inclusion in study group II cohort of this study, a subject
must meet all of the following criteria:
Participants
-Are healthy
- Are between the age of 18-40 years
- Are able to understand a written informed consent form
- Are able to follow the protocol of the study during the study period

Exclusion Criteria

Pregnant, uncertain about pregnancy status, currently breastfeeding, chronic
infection or autoimmune disease, immunocompromised, use of immunomodulatory
drugs, use of immunosuppressant medications

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Turnover rate of antigen-specific cells (group I)<br /><br>2. Turnover rate of functional T-cell subsets (group II)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Determining absolute numbers of antigen (polio, measles, HepA and HepB)<br /><br>specific T cells during the study<br /><br>Monitoring cytokine profile and IgG antibody levels in blood in response to the<br /><br>vaccine</p><br>