Comparative study to modify harmful blood pressure and heart rate changes during placement of a tube inside windpipe for securing airway with dexmedetomidine and esmolol

Phase 1

Not yet recruiting

• Conditions: Other intraoperative and postprocedural complications and disorders of the circulatory system, not elsewhere classified,

• Registration Number: CTRI/2019/05/019172
• Lead Sponsor: Vigneshwaran C

Brief Summary

Endotracheal intubation has become an integral part of the anaesthetic management, critical care of the patient. Endotracheal intubation and laryngoscopy causes a pressor response characterized by elevation in systolic and diastolic pressure within five seconds of laryngoscopy which further increases during insertion of the tube into the trachea.Such transient but marked sympathetic response manifesting as increase in heart rate (HR), blood pressure may be well-tolerated by normal fit American Society of Anesthesiologists (ASA) 1 patients. But such events are detrimental in individuals who have limited myocardial reserve due to coronary artery disease, cardiac dysrhythmia, cardiomyopathy, congestive heart failure, hypertension, and geriatric population.Tachycardia and hypertension associated with laryngoscopy and endotracheal intubation should be prevented to maintain the delicate balance between myocardial oxygen supply and demand during induction of general anaesthesia. The purpose of this study is to find out whether the bolus injection of dexmedetomidine 0.75mcg/kg given intravenously before 10 min prior to intubation provides consistent protection against pressor response during laryngoscopy and endotracheal intubation when compared with esmolol group and to attenuate the hemodynamic response to laryngoscopy and endotracheal intubation.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-05-15
• Study Start: 2019-05-16

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA 1 and ASA 2.

Exclusion Criteria

patients with ischemic heart disease, hypertension, Diabetes mellitus, pregnant, anticipated difficult airway, duration of laryngoscopy more than 20 seconds.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the clinical effects of dexmedetomidine and esmolol	SBP,DBP,MAP,Heart rate,SpO2 recording | At baseline | At 60 sec after infusion of dexmedetomidine/ | esmolol | Immediately after induction | At 1 min after intubation | At 3 min after intubation | At 5 min after intubation | At 10 min after intubation
SBP,DBP,MAP,Heart rate,SpO2 recording	SBP,DBP,MAP,Heart rate,SpO2 recording | At baseline | At 60 sec after infusion of dexmedetomidine/ | esmolol | Immediately after induction | At 1 min after intubation | At 3 min after intubation | At 5 min after intubation | At 10 min after intubation

Secondary Outcome Measures

Name	Time	Method
Attenuation of hemodynamic responses during laryngoscopy and endotracheal intubation.	SBP,DBP,MAP,Heart rate,SpO2 recording

Trial Locations

Locations (1)

Sri Manakula Vinayagar Medical College and Hospital; 🇮🇳 Pondicherry, PONDICHERRY, India

Sri Manakula Vinayagar Medical College and Hospital

🇮🇳Pondicherry, PONDICHERRY, India

Vigneshwaran C

Principal investigator

9894883196

wincmv26@gmail.com