Evaluating point-of-care prothrombin time measurements for cardiac surgery
Completed
- Conditions
- prothrombin timecoagulation status1006447710007593
- Registration Number
- NL-OMON40525
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 64
Inclusion Criteria
Ex-vivo study
- Healthy volunteers
- Age 18 * 90 years
- Informed consent;Clinical study in cardiac surgery
- Patients undergoing elective cardiothoracic surgery
- Age 18-90 years
- Preoperative hemoglobin of > 5.5 mmol/l
- Informed consent
Exclusion Criteria
Ex vivo study
- Subjects with hemostatic deficiencies or previous hemostatic problems
- Subjects using vitamin K antagonists, clopidogrel or dabigatran at the time of surgery.
- Pregnancy;Clinical study in cardiac surgery
- Re-operations and emergency operations
- Use of erythropoietin
- Hepatic or renal failure
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The International Normalized Ratio (INR) of the prothrombin time (PT) as<br /><br>measured with Coaguchek Plus or routine laboratory tests.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The ex vivo effect of different protamine:heparin ratio on the POC-PT. </p><br>