se of microRNAs in patients with Chagas disease
Not Applicable
- Conditions
- Chronic Chagas disease in indeterminate, cardiac without ventricular dysfunction and cardiac with ventricular dysfunction forms.B57.2
- Registration Number
- RBR-2md5dr
- Lead Sponsor
- Hospital São Rafael
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Chagas disease confirmed by 2 different serological tests; optimized drug therapy; NYHA functional class II-III-IV or patients with the indeterminate form; patients of any gender and aged 18 to 70 years.
Exclusion Criteria
Valvulopathy with hemodynamic consequences; chronic use of immunosuppressive agents; renal failure on current treatment by dialysis; acute infections or systemic infections in accordance with the definition of sepsis ACCP/SCCM (American College of Chest Phisicians/Society of Critical Care Medicine); abuse alcohol or illicit drugs (Based on DSM IV), any comorbidity with impact on survival in two years; liver, pulmonary, hematologic, neoplastic, bone, inflammatory or infectious diseases.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expected outcome: change in the expression profile of microRNAs on the chagasic patients in comparison to healthy patients, verified by PCR, observing a change in 10% in this expression profile.
- Secondary Outcome Measures
Name Time Method Expected outcome: change in the expression profile of microRNAs on patients with cardiac fibrosis in comparison to patients without fibrosis, verified by PCR, observing a change in 10% in this expression profile.