Analysis of T Cell Metabolism and Immune Phenotype During the Course of Acute Myeloid Leukemia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 77
- 主要终点
- T cell phenotype
研究概览
简要总结
The objective of this study was to analyze the T cell metabolism and immune phenotype in AML patients during the course of the disease before and after allo-HCT.
详细描述
Patients who experience relapse of acute myeloid leukemia (AML) after allogeneic hematopoietic cell transplantation (allo-HCT) have a dismal prognosis. Infusion of donor T cells can induce graft-versus-leukemia (GVL) effects, indicating the importance of intact T cell function for leukemia control. Recent studies have shown the importance of metabolic fitness for an effective T cell response.
In this study we have analyzed the T cell metabolism and immune phenotype in AML patients at different time points before and after allo-HCT.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •confirmed diagnosis of AML
- •age ≥ 18 years
- •peripheral blood sample available
- •written informed consent
- •ability to understand the nature of the study and the study related procedures and to comply with them
排除标准
- •age < 18 years
- •lack of informed consent
- •patients that cannot be classified in one of the 3 groups
结局指标
主要结局
T cell phenotype
时间窗: 4 years
T cell cytokine and effector molecule production
T cell metabolism
时间窗: 4 years
Extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) determined by live-cell metabolic assay using the Seahorse Analyzer
次要结局
- Metabolite abundance in serum(4 years)
研究者
Robert Zeiser
Director of the Division of Tumor Immunology
University of Freiburg