A clinical trial to study the effect of vitamin D in patients with gum diseases.

Phase 2

Completed

• Conditions: Health Condition 1: null- Chronic PeriodontitisHealth Condition 2: M272- Inflammatory conditions of jaws

• Registration Number: CTRI/2017/08/009193
• Lead Sponsor: Rajiv Gandhi University of Health Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2019-08-13
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Inclusion Criteria :

1.Study subjects should be >25 years of age.

2.Patients suffering from chronic periodontitis i.e.

a)Bleeding on probing

b)Probing pocket depth of >= 5 mm

c)Clinical attachment loss of >= 3 mm

3.Patients should be vitamin D sufficient (serum levels 30ng/ml and above) according to vitamin D council.

4.Systemically healthy individuals with minimum 20 teeth in occlusion.

Exclusion Criteria

Exclusion Criteria:

1.Patients with systemic diseases that can impair immune response such as diabetes mellitus, HIV, immunological disorder and hepatitis.

2.Patients on any systemic antibiotics, NSAIDS, steroid therapy and any other drugs which is known to affect the periodontal status.

3.Smokers and former smokers are excluded from the study.

4.Patients who have received periodontal treatment in the preceding year or who have taken antibiotics within the previous 3 months.

5.Pregnant or lactating women and those taking oral contraceptive drugs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Increase in GCF cathelicidine levels.Timepoint: 90 days.

Secondary Outcome Measures

Name	Time	Method
Improvement in epithelial barrier functionTimepoint: 90 days