Sigh35 and end-expiratory occlusion test assess fluid responsiveness in critically ill patients undergoing pressure support ventilation: a validation study.

• Conditions: Hemodinamically unstable ICU patients requiring fluid administration; Critically ill patients showing signs of tissue hypoperfusion; Hypotensive ICU patients; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12616001564448
• Lead Sponsor: antonio messina

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-11-11
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1) Acute circulatory failure defined by a systolic arterial pressure less than or equal to 90 mm Hg (or fall of systolic arterial pressure of at least 50 mm Hg in known hypertensive patients) and one or more of the following signs: 1) urinary flow less than or equal to 0.5 mL/kg/min for greater than or equal to 2 hours, 2) tachycardia greater than or equal to 100 bpm, or 3) presence of skin mottling. 2) PSV with inspiratory support level (PS) between 8 and 15 cmH2O and positive end-expiratory pressure (PEEP) between 5 and 10 cmH2O; 3) stable ventilatory pattern.

Exclusion Criteria

1) severe myocardial or valvular dysfunction; 2) cardiac arrhythmias; 3) severe acute respiratory distress syndrome (ARDS); 4) haemodialysis or continuous hemofiltration; 5) Body Mass Index equal or greater to 30; 6) altered arterial waveform; 7) diagnosis of pneumothorax.

Study & Design

• Study Type: Interventional
• Study Design: Not specified