Protein Blends (Soy, Whey and Casein) for Muscle Synthesis

Not Applicable

Completed

• Conditions: Muscle Synthesis
• Interventions: Other: Protein Blend

• Registration Number: NCT01358305
• Lead Sponsor: DuPont Nutrition and Health

Brief Summary

Soy protein is a high quality, plant-based protein that is comparable to milk, meat and eggs. Soy protein has a digestion rate (intermediate) compared to whey (fast) and casein (slow). This intermediate rate may allow soy protein to have an extended window of muscle protein synthesis that has not been monitored in previous studies. While most of the sports nutrition "recovery" products are dairy-based protein blends (high in branched-chain amino acids), soy protein offers additional benefits that can make an important contribution to these types of sports nutrition products. Soy protein contains approximately 300% more arginine and 30% more glutamine compared to whey protein and these two amino acids may bring additional benefits (immunity and hydration, respectively) to athletes. A "blend" of high-quality proteins (soy and dairy) may be the optimal sports nutrition product for athletes to consume following training.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2011-05-19
• Study First Submitted QC: 2011-05-20
• Study First Posted: 2011-05-23
• Primary Completion: 2012-08
• Study Completion: 2013-03
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-03
• Last Update Posted: 2019-10-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 19

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Protein Blend (soy, whey and casein)	Protein Blend	-
Whey Protein Isolate	Protein Blend	-

Primary Outcome Measures

Name	Time	Method
Muscle Protein Synthesis or Fractional synthesis rate (FSR)	baseline, 3 hours, 5 hours	The fractional synthesis rate (FSR) of mixed muscle proteins will be calculated from the incorporation rate of L-\[ring-13C6\]Phenylalanine into the mixed muscle proteins, and the free-tissue phenylalanine enrichment.

Secondary Outcome Measures

Name	Time	Method
oxidative and inflammatory markers	baseline, 3 hours, 5 hours	Proteins will be assessed that are markers of oxidative damage and inflammation (NFkB, IL-1, IL-6) and proteolysis (MuRF, MAFBx).
Phosphorylation of protein in muscle protein signaling pathways	baseline, 3 hours, 5 hours	Phosphorylation of mTOR, 4E-BP1, S6K1, S6, and eEF2 will be measured using Western blot techniques as previously described.

Trial Locations

Locations (1)

UTMB General Clinical Research Center, located in the John Sealy Hospital; 🇺🇸 Galveston, Texas, United States