Attention Bias Modification Treatment for Warzone-Related PTSD: A Randomized Clinical Trial Magnetoencephalography Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Will Posttraumatic Stress Disorder and Symptom decrease with intervention
研究概览
简要总结
Veterans with Posttraumatic Stress Disorder (PTSD) will be randomly assigned to either Attention Bias Modification Treatment (ABMT) designed to reduce bias toward threat or a placebo control condition not designed to change attention patterns. Outcome measures will be PTSD, anxiety, depression, and alexithymia symptoms as measured by standard psychological interviews and questionnaires. Participants will also be invited to participate in physiological testing before and after receiving AMBT or placebo to serve as additional outcome measures and assess brain functioning, heart rate, and muscle tension.
The investigators expect to see significant PTSD symptom reduction in the Attention Bias Modification Treatment (ABMT) group relative to the placebo control group in which no symptomatic relief is expected. At the end of the study, if ABMT is shown to be effective, we will offer active ABMT to those participants randomly assigned to the placebo arm if they would like to receive the treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 19 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Veterans with Posttraumatic Stress Disorder (PTSD) serving in United States Military after March 20, 2003.
排除标准
- •Schizophrenia
- •Bipolar Disorder
- •Obsessive Compulsive Disorder
- •Head Injury with Loss of Consciousness for more than 30 minutes
- •Active Alcohol/Substance Dependence in past 6 months
研究组 & 干预措施
Attentional Control Training
Attention control training using a computerized spatial attention taks (dot-probe) counter balances training toward and away from threat.
干预措施: Attention Bias Modification Training Protocol (Behavioral)
Attention Bias Modification Treatment
Attention bias modification training using a computerized spatial attention task (dot-probe) designed to alter threat-bias attention patterns away from threat.
干预措施: Attention Bias Modification Training Protocol (Behavioral)
结局指标
主要结局
Will Posttraumatic Stress Disorder and Symptom decrease with intervention
时间窗: 8 weeks
Using Clinician-Administered PTSD Scale (CAPS): The clinician-Administered PTSD Scale (CAPS) is a 30-item structured interview that corresponds to the DSM-IV criteria for PTSD (Blake, Weathers, Nagy, Kaloupek, Charney, \& Keane, 1995) to assess symptoms of PTSD outcome.
次要结局
- Other psychiatics symptoms (ie Depression, Anger, Anxiety)(8 weeks)