NCT04673227Unknown不适用
Cytometric Immunodiagnostics of Latent Tuberculosis Infection (LTBI) and the Influence of Previous BCG Vaccination - Pilot Study
Thomayer University Hospital2 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2020年1月2日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Peer-review publication of results of our study
研究概览
简要总结
TB-reactive immune cells will be tested in a multiparametric flow cytometry to distinguish an immune response for antigens of Mycobacterium spp. in TB disease/latent infection or a reaction after BCG vaccine.
详细描述
The goal of this project is the verification of current cytometric panel of detection antibodies in a wider panel of stimulative immunodominant antigens for CD4+ and CD8+ T cells in combination with adjuvants 2 in a in vitro activating test.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 4 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •active TB, contact with TB infection in previous 3 months before the study
排除标准
- •HIV positive patients
结局指标
主要结局
Peer-review publication of results of our study
时间窗: 2 years
次要结局
- Creation of new diagnostic tool and his comparision with existing IGRA test (QTF-GP and TST)(2 years)
研究者
Karolína Doležalová, M.D.
M.D.
Thomayer University Hospital
研究点 (2)
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