Diagnosis of Tuberculosis Infection in Health Care Workers Using Ex-vivo Interferon-gamma Assay
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 322
- 试验地点
- 2
- 主要终点
- Annual Incidence of Tuberculosis Infection Among Newly Employed Doctors and Nurses in Korea
研究概览
简要总结
The present study was to evaluate the usefulness of a whole-blood interferon-r release assays (IGRAs) as diagnostic tool of the latent tuberculosis infection for healthcare workers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •doctors and nurses newly hired at Samsung Medical Center between February, 2008 and November, 2008.
排除标准
- •Non-applicable
结局指标
主要结局
Annual Incidence of Tuberculosis Infection Among Newly Employed Doctors and Nurses in Korea
时间窗: QFT-IT test was performed at enrollment and repeated at point of one year after enrollment. So, the length of timw which from the start of the first test of very first participant to the end of second test of very last participant is 2 years.
The participants performed QuaniFERON-TB Gold In-Tube test (QFT-IT test). Annual infection of tuberculosis infection was evaluated with the conversion of QFT-IT test through annual check up of QFT-IT test. The definitions for QFT-IT test conversion was based on the CDC definition (Baseline IFN-r \< 0.35 IU/ml and follow-up IFN-r ≥ 0.35 IU/ml).
次要结局
- Negative Conversion Rate in Follow-up QuantiFERON-TB Gold In-Tube Test (QFT-IT Test) After Treatment of Latent Tuberculosis Infection (LTBI)(3 months after LTBI treatment)
研究者
Won-Jung Koh
MD, PhD, Associated professor, school of medicine, sungkyunkwan university
Samsung Medical Center