Neutropenic Fever, Inflammatory Markers and Sepsis in Haematological Patients
Completed
- Conditions
- Sepsis
- Interventions
- Other: Severe sepsis vs. non-severe sepsis
- Registration Number
- NCT00781040
- Lead Sponsor
- Kuopio University Hospital
- Brief Summary
The aim of this study is to find out whether inflammation markers including cardiac markers have predictive value in evaluation of pathogenesis of sepsis in neutropenic haematological patients.
- Detailed Description
Adult AML and ASCT patients with neutropenic fever. Observation of possible progress to severe sepsis or septic shock. Blood sample collection on days 0-3 (from the beginning of neutropenic fever).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 273
Inclusion Criteria
- diagnosis: acute myeloid leukaemia
- age under 70 years
- neutropenic fever
Exclusion Criteria
- age above 70 years
- no neutropenic fever
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Neutropenic patients Severe sepsis vs. non-severe sepsis Adult AML and ASCT patients with neutropenic fever.
- Primary Outcome Measures
Name Time Method This study evaluates epidemiology, microbiology and outcome of neutropenic fever and severe sepsis in haematological patients with special reference to the kinetics of inflammatory markers. Within neutropenic period after treatment This study evaluated epidemiology, microbiology and outcome of neutropenic fever and severe sepsis in haematological patients with special reference to the kinetics of specific inflammatory markers.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kuopio University Hospital
🇫🇮Kuopio, Finland