Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio as Predictors for Adverse Events in EVAR

Completed

• Conditions: Inflammation in EVAR
• Interventions: Other: NLR

• Registration Number: NCT04254211
• Lead Sponsor: University of Thessaly

Brief Summary

This study investigated the association of chronic inflammatory markers with the clinical outcome after endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm.

Detailed Description

The study included 230 consecutive AAA patients, treated electively by EVAR from March 2016 to February 2019. The values of simple inflammatory markers,neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), were measured pre- and postoperatively.Adverse events included any major adverse cardiovascular events (MACE), acute kidney injury and death from any cause.

Study Timeline

• Study Start: 2016-03-01
• Primary Completion: 2019-02-01
• Study Completion: 2019-11-01
• Study First Submitted: 2020-01-05
• Study First Submitted QC: 2020-02-02
• Study First Posted: 2020-02-05
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-27
• Last Update Posted: 2021-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 230

Inclusion Criteria

• AAA
• Elective
• EVAR

Exclusion Criteria

• Emergency
• Open surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
EVAR	NLR	Patinets with AAA, treated electively by EVAR. The values of simple inflammatory markers,neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), were measured pre- and postoperatively. Adverse events included any major adverse cardiovascular events (MACE), acute kidney injury and death from any cause

Primary Outcome Measures

Name	Time	Method
PLR acute kidney injury (AKI)	Day 4 postopertively	PLR indicator for acute kidney injury (AKI)
PLR major cardiovascular events (MACE)	Day 4 postopertively	PLR indicator for major cardiovascular events (MACE)
NLR acute kidney injury (AKI)	Day 4 postopertively	NLR indicator for acute kidney injury (AKI)
NLR death	Day 4 postopertively	NLR indicator for death
NLR major cardiovascular events (MACE)	Day 4 postopertively	NLR indicator for major cardiovascular events (MACE)
PLR death	Day 4 postopertively	PLR indicator for death

Trial Locations

Locations (1)

Univeristy of Thessaly; 🇬🇷 Larissa, Thessaly, Greece