Use of Reticulocyte Ratio and Neutrophil / Lymphocyte Ratio in the Diagnosis of Ventilator-associated Pneumonia

Completed

• Conditions: Ventilator-associated Pneumonia (VAP)
• Interventions: Diagnostic Test: reticulocyte/hemoglobin (Ret-He) ratio

• Registration Number: NCT04620941
• Lead Sponsor: Muğla Sıtkı Koçman University

Brief Summary

In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.

Detailed Description

Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in the intensive care unit, affecting one third of patients requiring mechanical ventilation for a noninfectious reason. In the case of inflammation, iron retention increases in the reticuloendothelial system cells; hemoglobin (Hb) synthesis is reduced. It has been reported that the ratio of reticulocyte / hemoglobin (Ret-He) decreases in the early period in community-acquired pneumonia patients and may be a guide as a marker of inflammation. In addition, the neutrophil / lymphocyte ratio (NLR) is a parameter studied in the hemogram panel. It provides a clue to both the presence of infection and the focus of the infection.

In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.

Study Timeline

• Study First Submitted: 2020-11-03
• Study First Submitted QC: 2020-11-03
• Study First Posted: 2020-11-09
• Study Start: 2022-02-21
• Primary Completion: 2023-09-21
• Study Completion: 2023-12-21
• Status Verified: 2024-11
• Last Update Submitted: 2024-11-04
• Last Update Posted: 2024-11-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

-Patients who need mechanical ventilation for longer than 48 hours for a noninfectious reason in the intensive care unit

Exclusion Criteria

• Pulmonary or extrapulmonary infection before mechanical ventilation,
• severe immunosuppression,
• bleeding in the gastrointestinal system,
• using corticosteroids,
• neoplastic disease history

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ventilator-associated pneumonia	reticulocyte/hemoglobin (Ret-He) ratio	Ret-He values will be studied on the day (1st day), 4th and 7th days of VID diagnosis in patients receiving mechanical ventilation support in the intensive care unit. The hemogram, CRP, and NLR values that are routinely studied in the intensive care unit will be recorded. In addition, in case of infection, the routinely studied procalcitonin value will also be recorded. The patient's age, gender, APACHE II, SOFA scores will be recorded; respiratory system examination, fever, the mental status evaluation will be done daily.

Primary Outcome Measures

Name	Time	Method
Early inflammation markers for VAP	7 days	To investigate the use of NLR and Ret-He value as early inflammation markers for VAP.

Secondary Outcome Measures

Name	Time	Method
morbidity and mortality	7 days	To compare the effects of Ret-He and NLR values on morbidity and mortality with other inflammation markers

Trial Locations

Locations (1)

Mugla Sitki Kocman Universty; 🇹🇷 Muğla, Kötekli, Turkey