Biological Phosphocalcic Metabolism and Coronary Artery Calcifications
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 83
- 试验地点
- 1
- 主要终点
- plasma levels of FGF23 according to the calcium score, determined by an ELISA method
研究概览
简要总结
Study a sample of patients in primary prevention, moderate cardiovascular risk (n = 83 patients), with normal, non-diabetic renal function. The investigators quantify the phophocalcic intake and excretion, realizing a food examination and a urine collection of 24 particular. The investigators will measure plasma levels of FGF23 serum calcium, phosphatemia, the investigators will calculate the tubular reabsorption of phosphate. The investigators will conduct a quantitative assessment of coronary calcification by a non-injected CT scan, measuring semi automated way Agatston calcium score. There will be an analysis of collinearity. An adjustment will be made for confounding variables in a generalized linear regression model.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospitalization for a cardiovascular check in the Detection Centre and the Atherosclerosis Prevention (CHU Rangueil Toulouse)
- •In primary prevention of coronary heart disease
- •Introducing an intermediate cardiovascular risk according to the European SCORE equation, that is to say, a risk of cardiovascular death at 10 years greater than or equal to 1% and less than 5%
- •signed the informed consent,
排除标准
- •Chronic renal failure patients with an estimated GFR less than 60 mL / min / 1.73m2, due to alterations in phosphate metabolism,
- •Patients receiving glucose-lowering therapy,
- •Patients with a fasting blood glucose greater capillary or equal to 1.10 g / l, confirmed by a plasma glucose greater than or equal to 1.10g / l.
- •The diuretic therapy patients (due to a change in urinary electrolytes)
- •HIV-positive patients for HIV, antiretroviral (due to a change in urinary electrolytes)
- •Pregnant women,
- •Patients under judicial protection, guardianship or trusteeship.
结局指标
主要结局
plasma levels of FGF23 according to the calcium score, determined by an ELISA method
时间窗: 1 day
次要结局
未报告次要终点