Elucidation of individual differences in blood concentration of posaconazole in patients with blood diseases and analysis of the relationship with clinical laboratory test values
Not Applicable
Recruiting
- Conditions
- Blood dyscrasia
- Registration Number
- JPRN-UMIN000045046
- Lead Sponsor
- Hamamatsu University School of Medicine Department of Hospital Pharmacy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Not provided
Exclusion Criteria
1) Those who the doctor deems inappropriate 2) Those who did not consent to participate in this study 3) Patients with severe liver or renal dysfunction 4) Patients taking azole antifungal drugs other than PSCZ
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1 Blood concentration (total concentration, free form concentration) of PSCZ and its metabolites, free form fraction 2 Factors that change blood dynamic parameters (clinical test values, diseases, combination drugs, inflammatory markers, hepatic / renal function marker concentrations, pharmacokinetic-related biomarker concentrations) 3 Gene polymorphism of drug-metabolizing enzymes (CYP3A4, CYP3A5, UGT1A), drug transport carriers (ABCB1, OATP1B), blood microRNA concentration 4 Blood concentration of concomitant drugs (tacrolimus, cyclosporine, letermovir) (only when used in combination)
- Secondary Outcome Measures
Name Time Method