Efficacy of Dexamethasone in Attenuation of Postinduction Hypotension in Geriatric Patients Undergoing General Anesthesia

Phase 4

Completed

• Conditions: Hypotension
• Interventions: Other: Placebo; Drug: Dexamethasone

• Registration Number: NCT04908592
• Lead Sponsor: Ain Shams University

Brief Summary

* Geriatric patients who undergo general anesthesia experience post induction hypotension which is treated with intravenous fluids and ephedrine. The main cause of post-induction hypotension is the decrease in the sympathetic outflow causing arterial vasodilatation, a decrease in venous return and consequently the activation of the Bezold Jarish reflex (BJR) that elicits a triad of bradycardia, vasodilatation and further hypotension. BJR is elicited by activation of 5-HT3 receptors within the intracardiac vagal nerve endings.

* Glucocorticoids in general inhibit 5-HT3 expression and dexamethasone was found to decrease the level of 5-HT3 in the cerebral cortex and hippocampus in developing rats. So, the research team hypothesizes that dexamethasone can attenuate the postinduction hypotension in geriatric patients undergoing general anesthesia if administered preoperatively.

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study First Submitted: 2021-05-27
• Study First Submitted QC: 2021-05-28
• Study First Posted: 2021-06-01
• Study Start: 2021-06-15
• Primary Completion: 2021-09-15
• Study Completion: 2021-09-15
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-21
• Last Update Posted: 2021-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. American Society of Anesthesiologists (ASA) Physical Status Class-I and II.
2. Elective surgery under general anesthesia.

Read More

Exclusion Criteria

1. Emergency surgeries.
2. Ischemic heart disease.
3. Peptic ulcer & active infection.
4. Psychiatric disorder.
5. Patients on steroids or serotonin related medications (e.g., selective serotonin reuptake inhibitor).

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
C Group (50 patients)	Placebo	-
D Group (50 patients)	Dexamethasone	-

Primary Outcome Measures

Name	Time	Method
The proportion of patients with hypotension (25% decrease below the baseline for mean blood pressure (mmHg).	intraoperative	The proportion of patients with hypotension (25% decrease below the baseline for mean blood pressure (mmHg).

Trial Locations

Locations (1)

Ain-Shams University Hospitals; 🇪🇬 Cairo, Egypt