Supervised exercise for people with myositis

Not Applicable

Conditions: idiopathic inflammatory myopathies
Inflammatory and Immune System - Autoimmune diseases
Inflammatory and Immune System - Connective tissue diseases

Registration Number: ACTRN12624000802505

Lead Sponsor: The University of Sydney

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot yet recruiting

Sex: All

Target Recruitment: 32

Inclusion Criteria

Greater than or equal to 18 years of age

Diagnosis of dermatomyositis, polymyositis or immune-mediated necrotizing myopathy (IMNM), made by a medical practitioner, and in accordance with European league against rheumatism (EULAR)/American college of rheumatology (ACR) Classification Criteria for Adult and Juvenile Idiopathic inflammatory myopathy (IIM) and their Major Subgroups (High probability more than 55% on calculator for IIM).

Disease duration greater than 3months

History of significant muscle inflammation (myositis) that has impacted health and been a major consideration in treatment decisions as judged by the treating physician

Willingness to provide informed consent and willingness to participate and comply with the study requirements

Deemed safe to exercise according to the Exercise and Sport Science Australia (ESSA) pre-screening form and baseline clinical assessments

Exclusion Criteria

Less than 18 years of age

Inclusion Body Myositis (IBM)

Amyopathic Dermatomyositis (ADM)

Contraindication or inability to exercise as determined by the ESSA pre-screening form and baseline clinical assessments

Currently pregnant or planning pregnancy

Diagnosis of condition(s) that may limit ability and safety to perform exercise (e.g., unstable cardiovascular disease, uncontrolled congestive heart failure, known heart failure)

Active malignancy

Severe interstitial lung disease (ILD) with a diffusing capacity of the lungs for carbon monoxide (DLCO) <40% and/or a forced vital capacity (FVC) less than 60%

Renal impairment (estimated glomerular filtration rate (GFR) less than 30mL/min/1.73m2)