Thyroid Nodule Gene Sequencing in a Danish Population - a Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Thyroid Nodule (Diagnosis)
- Sponsor
- Aarhus University Hospital
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Circulating tumor DNA
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population.
Patients with thyroid nodules suspected of malignancy is included prospectively.
Tissue samples are collected for molecular analyses form surgical specimens and bloodsamples, and preoperative clincial features are registered.
Investigators
Kristine Zøylner Rubeck
Principal investigator
Aarhus University Hospital
Eligibility Criteria
Inclusion Criteria
- •Thyroid nodule \>1.5 cm
- •BSRTC: IV, V, og VI
Exclusion Criteria
- •No surgical specimen available
- •Purely cystic nodules
Outcomes
Primary Outcomes
Circulating tumor DNA
Time Frame: Two years
Whole genome sequencing of leucocyt DNA and circularing DNA
DNA alterations
Time Frame: Two years
Whole genome sequencing by next generation sequencing
DNA methylation
Time Frame: Two years
Whole Genome Bisulfite Sequencing
RNA alterations
Time Frame: Two years
Total RNA sequencing including circular RNA, micro RNA and messenger RNA