Thyroid Nodule Gene Sequencing in a Danish Population
Not Applicable
Active, not recruiting
- Conditions
- Thyroid Nodule (Diagnosis)Thyroid Cancer
- Registration Number
- NCT05377736
- Lead Sponsor
- Aarhus University Hospital
- Brief Summary
This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population.
Patients with thyroid nodules suspected of malignancy is included prospectively.
Tissue samples are collected for molecular analyses form surgical specimens and bloodsamples, and preoperative clincial features are registered.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Thyroid nodule >1.5 cm
- BSRTC: IV, V, og VI
Exclusion Criteria
- No surgical specimen available
- Purely cystic nodules
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Circulating tumor DNA Two years Whole genome sequencing of leucocyt DNA and circularing DNA
DNA alterations Two years Whole genome sequencing by next generation sequencing
DNA methylation Two years Whole Genome Bisulfite Sequencing
RNA alterations Two years Total RNA sequencing including circular RNA, micro RNA and messenger RNA
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Aarhus Universityhospital
🇩🇰Aarhus N, Denmark
Aarhus Universityhospital🇩🇰Aarhus N, Denmark