Bi-level Positive Airway Pressure for Respiratory Distress Syndrome in Twins:A Randomized Controlled Trials
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- nCPAP
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
- Enrollment
- 300
- Locations
- 1
- Primary Endpoint
- intubation rate
- Last Updated
- 5 years ago
Overview
Brief Summary
The investigators compared advantages and disadvantages of two forms of noninvasive respiratory support -bi-level positive airway pressure(BiPAP) or nasal continuous positive airway pressure (nCPAP) -as a primary mode of ventilation in preterm twins infants with respiratory distress syndrome
Detailed Description
Invasive ventilation is related to development of adverse pulmonary and nonpulmonary outcomes in ventilated infants. Various modes of noninvasive respiratory support are being increasingly used to minimize the incidence of bronchopulmonary dysplasia (BPD). The aim of this trial to compare the effects of bi-level positive airway pressure(BiPAP) and nasal continuous positive airway pressure (NCPAP) in preterm twins infants as the primary mode.
Investigators
Ma Juan
Principal Investigator
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Eligibility Criteria
Inclusion Criteria
- •Gestational age (GA) is from 26 to 37 weeks;
- •Diagnosis of respiratory distress syndrome. The diagnosis of respiratory distress syndrome will be based on clinical manifestations (tachypnea, nasal flaring and or grunting) and chest X-ray findings;
- •Respiratory distress syndrome Silverman score \>5;
- •Informed parental consent has been obtained.
Exclusion Criteria
- •Severe respiratory distress syndrome requiring early intubation according to the American Academy of Pediatrics guidelines for neonatal resuscitation;
- •Major congenital malformations or complex congenital heart disease;
- •Group B hemolytic streptococcus pneumonia, septicemia, pneumothorax, pulmonary hemorrhage;
- •Cardiopulmonary arrest needing prolonged resuscitation;
- •transferred out of the neonatal intensive care unit without treatment.
Outcomes
Primary Outcomes
intubation rate
Time Frame: within 7 days
the baby was intubated