Constipation and Gut Transit in DMD Patients
- Conditions
- DMDConstipation
- Interventions
- Device: SmartPill ingestion
- Registration Number
- NCT01890616
- Lead Sponsor
- Children's Hospital Medical Center, Cincinnati
- Brief Summary
In this research study the investigators want to screen Duchenne Muscular Dystrophy (DMD) patients for signs and symptoms of constipation in patients over 18.
The investigators hypothesized:
* DMD patients have a high prevalence of constipation than in the general population.
* Prevalence of constipation will increase with age and with worsening functional status.
- Detailed Description
The following procedures will take place during the study.
Constipation Assessment:
* The patient will be asked to complete a questionnaire about any symptoms of constipation.
* A physician from the study team will perform an abdominal physical exam
* The patient will have routine x-rays that monitor for spine compression fractures. These films will also be used to assess stool content.
Clinical Information The following information will also be collected during the clinic visit ;
* Age at diagnosis and genetic mutation
* Age at loss of ambulation if applicable
* Medications
* Functional status
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 8
- Patients with a diagnosis of Duchenne Muscular Dystrophy (based on clinical presentation and verified by compatible muscle biopsy or known dystrophin gene mutation).
- Age greater than or equal to 18 years old
- None
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Motility SmartPill ingestion This arm will ingest the SmartPill.
- Primary Outcome Measures
Name Time Method GI transit times up to 5 days Gi transit times will be computed by an investigator.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Cincinnati Children's Hospital Medical Center
🇺🇸Cincinnati, Ohio, United States