The role of β-adrenergic stress hormones in Eye Movement Desensitization and Reprocessing (EMDR). Part I: the effects of β-adrenergic receptor antagonist propranolol on the plasticity of emotionally arousing episodic memories.

Completed

• Conditions: Geen aandoening: geneesmiddel wordt gebruikt om de onderliggende neurobiologische processen te onderzoeken van een therapie voor PTSD, namelijk EMDR; Neurobiology of EMDR; underlying mechanisms of EMDR therapy

• Registration Number: NL-OMON40004
• Lead Sponsor: niversiteit Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-08-05
• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

- Passing the medical screening (ECG, blood pressure and heart rate examination, two-step test and interview)
- Age 18-35
- BMI 17.5-26
- Normal (or corrected to normal) vision
- In females: the use of reliable contraceptives (birth control pills or a hormonal intrauterine device)

Exclusion Criteria

Assessed with physical exam:
- Abnormal ECG
- Systolic blood pressure < 60mmHg; Diastolic blood pressure < 90 mmHg
- Heart rate < 60 bpm or > 100 bpm
- No <10% increase in heart rate after 1 minute of stepping up and down a stepladder.;Assesed with interview:
- Familiarity with EMDR and/or prior participation in EMDR research
- Lifetime history of psychiatric disorder (depression, mania, psychosis, anxiety)
- Lifetime history of neurological disease (attention/memory problems and disorders, epilepsy, convulsions)
- Lifetime history of any cardiovascular problem, coronary insufficiency, congestive heart failure, heart block, bradycardia, myocardial infarction, hypotension, chronic obstructive pulmonary disease, bronchial asthma, renal disorders, liver disorders, uraemia, hyperthyroidism, acidosis.
- Early age cardiovascular problems in first degree family members
- Fainting easily (can be indicative of cardiovascular problems).
- Inability to adequately read or speak Dutch
- Use of any contraindicative medication:
- Medication that decreases blood pressure, or cardiac contractility or conductivity
- Medication for migraine, dizziness, asthma, tuberculosis, psoriasis
- Medication that lowers blood sugar levels
- Anti-inflammatory painkillers
- Anti-depressives
- Anti-psychotics
- Anxiolytics
- Antacids
- Recreational drug use other than alcohol in the past 3 months
- Known sensitivity to propranolol
- Daily smoking (>=10 cigarettes per day)
- Excessive drinking (>=4 glasses per day)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The emotionality and vividness of recollected memories at pretest (baseline),<br /><br>posttest (after medication intake and each experimental manipulation) and after<br /><br>24 hour follow-up measured with corrugator EMG, HR, SC, a VAS for emotionality,<br /><br>and a VAS for vividness.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>