NL-OMON40004CompletedNot Applicable
The role of β-adrenergic stress hormones in Eye Movement Desensitization and Reprocessing (EMDR). Part I: the effects of β-adrenergic receptor antagonist propranolol on the plasticity of emotionally arousing episodic memories. - The role of β-adrenergic stress hormones in EMDR: a propranolol study
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- niversiteit Utrecht
- Enrollment
- 60
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •- Passing the medical screening (ECG, blood pressure and heart rate examination, two-step test and interview)
- •- Age 18-35
- •- BMI 17.5-26
- •- Normal (or corrected to normal) vision
- •- In females: the use of reliable contraceptives (birth control pills or a hormonal intrauterine device)
Exclusion Criteria
- •Assessed with physical exam:
- •- Abnormal ECG
- •- Systolic blood pressure < 60mmHg; Diastolic blood pressure < 90 mmHg
- •- Heart rate < 60 bpm or > 100 bpm
- •- No <10% increase in heart rate after 1 minute of stepping up and down a stepladder.;Assesed with interview:
- •- Familiarity with EMDR and/or prior participation in EMDR research
- •- Lifetime history of psychiatric disorder (depression, mania, psychosis, anxiety)
- •- Lifetime history of neurological disease (attention/memory problems and disorders, epilepsy, convulsions)
- •- Lifetime history of any cardiovascular problem, coronary insufficiency, congestive heart failure, heart block, bradycardia, myocardial infarction, hypotension, chronic obstructive pulmonary disease, bronchial asthma, renal disorders, liver disorders, uraemia, hyperthyroidism, acidosis.
- •- Early age cardiovascular problems in first degree family members
- •- Fainting easily (can be indicative of cardiovascular problems).
- •- Inability to adequately read or speak Dutch
- •- Use of any contraindicative medication:
- •- Medication that decreases blood pressure, or cardiac contractility or conductivity
- •- Medication for migraine, dizziness, asthma, tuberculosis, psoriasis
- •- Medication that lowers blood sugar levels
- •- Anti-inflammatory painkillers
- •- Anti-depressives
- •- Anti-psychotics
- •- Anxiolytics
- •- Antacids
- •- Recreational drug use other than alcohol in the past 3 months
- •- Known sensitivity to propranolol
- •- Daily smoking (>=10 cigarettes per day)
- •- Excessive drinking (>=4 glasses per day)
Investigators
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