DRKS00032507招募中Unknown
The Effect of Stress on Neuroendocrine Markers and Functional Connectivity in Children and Adolescents with Depressive and Anxiety Disorders
Klinik und Poliklinik für Kinder- und Jugendpsychiatrie der Universität Regensburg am Bezirksklinikum Regensburg0 个研究点目标入组 90 人开始时间: 2023年8月28日最近更新:
适应症
试验速览
- 阶段
- Unknown
- 状态
- 招募中
- 发起方
- 入组人数
- 90
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Non-randomized controlled study
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 12 Years 至 17 Years（—）
- 性别
- All
入选标准
- •General inclusion criteria
- •- Sufficient understanding of the German language
- •- Informed consent of the study participants and their legal guardians
- •- Age at the beginning of the study participation: 12-17 years
- •Inclusion criteria patient group depressive disorders
- •- Primary diagnosis of a depressive disorder according to the diagnostic criteria of the DSM-V classification and ICD-10 (Moderate depressive episode (F32.1), Major depressive episode without psychotic symptoms (F32.2), severe depressive episode with psychotic symptoms, Recurrent depressive disorder, current moderate episode (F33.1), Recurrent depressive disorder, current major episode without psychotic symptoms (F33.2), Recurrent depressive disorder, current major episode with psychotic symptoms (F33.3))
- •Inclusion Criteria Patient Group Depressive disorders with comorbid anxiety disorder.
- •- Primary diagnosis of depressive disorder according to Inclusion criteria patient group depressive disorders.
- •- Additional diagnosis of an anxiety disorder according to the diagnostic criteria of the DSM-V classification and ICD-10 (agoraphobia (ICD-10 F40.0) without/with details a panic disorder (F40.00, F40.01), social phobias (F40. 1), panic disorder (F41.0), generalized anxiety disorder (F41.1), emotional disorder with separation anxiety of childhood (F93.0), disorders with social anxiety of childhood (F93.2), generalized anxiety disorder of childhood (F93.80)
- •Inclusion criteria healthy control group
- •- No psychiatric and neurological pre-existing conditions
- •- No presence of a mental disorder requiring treatment
- •- No current or past outpatient, partial hospitalization, or full hospitalization psychiatric or psychotherapeutic interventions
排除标准
- •General exclusion criteria
- •- Pre-existing neurological or endocrinological disorders
- •- Known genetic syndromes
- •- Past traumatic brain injury
- •- Use of glucocorticoid-containing medications
- •- Pregnancy or lactation
- •- Premature pubertal development (pubertas precox vera) due to hormonal status deviating from the norm (Brämswig & Dübbers, 2009)
- •- Known intellectual impairment (IQ<80).
- •- School education: Special school
- •- Acute suicidal tendency
- •- Other neurological disorders affecting brain development and physiology
- •- Lack of consent
- •- MRI-specific contraindications: metallic foreign objects, tattoos with metal-containing pigments, claustrophobia, pacemakers and defibrillator systems, cochlear implant, implanted insulin pumps, non-removable piercings made of magnetic materials.
- •- At least one of the following mental disorders (current or past).
- •o Psychotic disorder
- •o Bipolar disorder
- •o Anorexia nervosa
- •o Substance dependence
- •Exclusion Criteria Patient Group Depressive Disorders
- •- Categorical diagnosis of anxiety disorder
- •Exclusion criteria control group
- •- Pre-existing psychiatric and neurological conditions
- •- Presence of a mental disorder requiring treatment
- •- Current or past outpatient, inpatient, or partial inpatient psychiatric or psychotherapeutic interventions
- •- Use of psychotropic drugs and neuroleptics
研究者
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