Neuromodulation by Non-invasive Brain Stimulation (NEUROMOD)
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- University Hospital, Grenoble
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Effect of the neuromodulation on the behavioral performances during the access in semantics
- Last Updated
- 7 years ago
Overview
Brief Summary
The main objective of this study is to estimate the effect of the neuromodulation on the behavioral performances during the access in semantics according to the age of the individuals.
Neuromodulation by non-invasive stimulation allows to explore the functioning of the brain by exciting or by inhibiting localized cortical zones. The modulation of the performances in cognitive tasks, further to the neuromodulation of these zones, allows to deduce on their functional roles.
Detailed Description
The objective of this project is to determine the changes of behavioral performances (time of answer, percentage of correct answers) further to the neuromodulation. The specific question is to estimate the effect on the performances of access at the semantic representations of this method, according to the age. One of the hypotheses in the research on the normal ageing is the difficulty of access to these representations (fundamental process for the cognitive functions, such as the language and the memory) at the healthy elderly. By using the neuromodulation the investigators wish to explore this hypothesis and to understand if the neuromodulation can have a beneficial effect on the improvement of the behavioral performances of the elderly.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Major healthy Subject ( 18 - 85 years)
- •Right-hander
- •Signed Informed consent
- •A medical examination must be made before the participation for the research
- •Membership in or beneficiary of a national insurance scheme
- •Non inclusion Criteria:
- •Subject under age 18 and of more than 85 years.
- •Contraindications in the practice of MRI, TMS and tES
- •Existence of a severe affection on the general plan: cardiac, respiratory, hematological, renal, hepatic, cancerous
- •Regular taking of anxiolytic, sedative, antidepressant, neuroleptic
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Effect of the neuromodulation on the behavioral performances during the access in semantics
Time Frame: 3 hours
Evaluation of the changes of the behavioral performances before and after the neuromodulation by non-invasive cortical stimulation according to the age. More exactly, the investigators shall compare response times before and after neuromodulation between both age groups (18-49 years and 50-85 years), by testing the interaction between the effect of the neuromodulation and the age.
Secondary Outcomes
- Estimate the effect of tES on the cerebral functional activity, by comparing blood-oxygen-level dependent (BOLD ) signal or functional MRI before and after tES according to the age (18-49 years vs 50-85 years).(3 hours)
- Estimate the effect of transcranial Electrical Stimulation (tES) on the cognitive performances by neuropsychological scores, according to the age.(3 hours)
- Estimate the effect of the Transcranial Magnetic Stimulation (TMS) on the cognitive performances by neuropsychological scores, according to the age.(3 hours)
- Estimate the effect of the TMS on the intellectual functional activity, according to the age.(3 hours)
- Estimate the effect of the neuromodulation on the behavioral performances(3 hours)