Effects of Noninvasive Brain Stimulation Techniques on BDNF Levels

Not Applicable

• Conditions: Depression; Schizophrenia

• Registration Number: NCT02652832
• Lead Sponsor: Hôpital le Vinatier

Brief Summary

The aim of this study is to investigate the effects of non invasive brain stimulation - NIBS - techniques (Electroconvulsivotherapy - ECT, transcranial Direct Current Stimulation - tDCS, repetitive transcranial magnetic stimulation - rTMS) on serum Brain Derived Neurotrophic factor (BDNF) levels in patients with depression and schizophrenia. Four blood samples will be collected in each participants, one before the NIBS sessions, and 3 after the completion of NIBS protocols: one immediately after the end of the NIBS sessions, a second one week after and a last one month after. Two blood samples separated by one month will also be collected in a a group of healthy volunteers.

Detailed Description

The hypothesis is that NIBS will modulate BDNF levels and that the modification in serum BDNF levels will be correlated with clinical improvements in the sample of patients.

Study Timeline

• Study Start: 2010-12
• Study First Submitted: 2015-10-19
• Study First Submitted QC: 2016-01-08
• Study First Posted: 2016-01-12
• Status Verified: 2018-02
• Last Update Submitted: 2018-07-31
• Last Update Posted: 2018-08-01
• Primary Completion: 2018-12-31
• Study Completion: 2019-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• in the depression group: DSM IV criteria of MDD; HDRS17> 22; stage 2 of resistance; received rTMS or ECT
• in the schizophrenia group DSM IV criteria of schizophrenia; pharmaco-resistance of symptoms (either negative symptoms or auditory verbal hallucination); received rTMS or tDCS
• in the healthy volunteers group : to not have axis I of DSM IV diagnosis; no siblings with axis I DSM IV diagnosis

Exclusion Criteria

• less than 18 years old
• pregnancy
• received benzodiazepine

In the depression and schizophrenia group:

• bipolar disorder
• other axis I of DSM IV diagnosis (excluding for Tobacco use disorder)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
serum BDNF levels	from baseline to one month

Trial Locations

Locations (1)

Hopital Le vinatier; 🇫🇷 Bron, France