Effect of Intradialytic Exercises in Chronic Kidney Disease Patients

Not Applicable

Completed

Interventions: Device: sand bags
Device: hemodialysis sessions
Device: leg pedaling cycling device

Brief Summary: the purpose of this study is to compare between intradialytic aerobic versus resistive exercises on immunity response in patients with chronic kidney disease.

Detailed Description: The patients of this study will randomly assigned into three equal groups (n=20)

1. Study Group A (20 patients) will receive intradialytic aerobic exercise and medical treatment.

2. Study Group B (20 patients) will receive intradialytic resistive exercise and medical treatment.

3. Control Group C (20 patients) will receive medical treatment only (HD session and drugs) Each patient will receive the treatment program three times per week for three months.

Recruitment & Eligibility

Inclusion Criteria

Sixty men chronic kidney disease (grade III RF). They received regular hemodialysis sessions at least one year ago, each one for four hours, three times per week.
They had a history of type II Diabetes more than five years.
Their age will be ranged from 50-60 years old.
They are Fit for exercise by functional assessment using six minute walk test.
Their Hemoglobin level more than 10 g\dl.
Their Body Mass Index (BMI) will be ranged from "18.5" to "24.9".

Exclusion Criteria

Severe cardiac disorders.
Severe orthopedic problems (for example fractures).
Hepatic encephalopathy.
Preexisting neuromuscular diseases (e.g. myasthenia gravis). •Severe chest diseases.
Spinal cord injuries involved the phrenic nerve.
Uncontrolled diabetes or hypertension
Patients receiving inefficient hemodialysis session.
Patients with other cause for inflammation e.g. malignancy and autoimmune disease.
Active bleeding as alveolar hemorrhage, hemoptysis.
Physical limitation that would limit cycling.

Arm && Interventions

Group	Intervention	Description
study group B resistive exercise	sand bags	receive hemodialysis sessions and intradialytic resistive exercise
control group C	hemodialysis sessions	receive hemodialysis sessions
study group A aerobic exercise	leg pedaling cycling device	receive hemodialysis sessions and intradialytic aerobic exercise
study group A aerobic exercise	hemodialysis sessions	receive hemodialysis sessions and intradialytic aerobic exercise
study group B resistive exercise	hemodialysis sessions	receive hemodialysis sessions and intradialytic resistive exercise

Primary Outcome Measures

Name	Time	Method
Total leukocyte count	baseline , 12 weeks for each patient	measured by (cell/mcl)\\\\1000
Concentration of immunoglobulin g	baseline , 12 weeks for each patient	measured by mg/dl
Concentration of HbA1c	baseline , 12 weeks for each patient	measured by percentage of blood sugar last 3 months
lymphocyte count	baseline , 12 weeks for each patient	measured by (cell/mcl)\\\\1000
neutrophil count	baseline , 12 weeks for each patient	measured by (cell/mcl)\\\\1000

Secondary Outcome Measures

Name	Time	Method
hemoglobin concentration	baseline , 12 weeks for each patient	measured by (g/dl)
six minute walk test	baseline , 12 weeks for each patient	measured by meter
(KDQOL-SFTM) questionnaire	baseline , 12 weeks for each patient	measured by scoring a score-value from 0 (worst health status) to 100 (best health status) was obtained
thrombocytes count	baseline , 12 weeks for each patient	measured by (cell/mcl)\\\\1000
diastolic blood pressure	baseline , 12 weeks for each patient	measured by mmHg
Systolic blood pressure	baseline , 12 weeks for each patient	measured by mmHg

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