Effect of Pregabalin on the Postoperative Analgesia in RFA of Focal Lesions in the Liver

Phase 4

• Conditions: Hepatocellular Cancer
• Interventions: Drug: Pregabalin 150mg; Other: Placebo

• Registration Number: NCT03151213
• Lead Sponsor: Sherief Abd-Elsalam

Brief Summary

The study aimed to investigate the preemptive analgesia efficacy of of preemptive pregabalin for the postoperative pain management after radiofrequency ablation (RFA) of liver cancer.

Detailed Description

Our data will investigate if preemptive administration of pregabalin will have a role in reducing postoperative pain after radiofrequency ablation (RFA) of liver cancer.

Study Timeline

• Study Start: 2017-05-01
• Study First Submitted: 2017-05-11
• Study First Submitted QC: 2017-05-11
• Study First Posted: 2017-05-12
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-23
• Last Update Posted: 2018-08-27
• Primary Completion: 2019-12
• Study Completion: 2019-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• HCC patients, Child A, B, scheduled for Radiofrequency ablation of HCC.

Exclusion Criteria

• Encephalopathy, Renal impairment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pregabalin	Pregabalin 150mg	Pregabalin 150 mg before intervention
Placebo	Placebo	Placebo before intervention

Primary Outcome Measures

Name	Time	Method
visual analogue pain scale (VAS Pain) post operatively	2 weeks	Amplitude of pain postoperatively

Trial Locations

Locations (1)

Tanta university - faculty of medicine; 🇪🇬 Cairo, Elgharbia, Egypt