Efficacy of Pre-operative Oral Pregabalin in Ambulatory Inguinal Hernia Repair for Post Operative Pain
- Registration Number
- NCT01450345
- Lead Sponsor
- University of Malaya
- Brief Summary
The study carry out is to determine whether the use of oral pregabalin premedication to assess the analgesic efficacy, opiod sparing, adverse effect and clinical value in post-operative pain management.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 72
Inclusion Criteria
- Clinical diagnosis of inguinal hernia
- Patient undergo operation under daycare basis
- ASA I-II
- Written consent
Exclusion Criteria
- ASA > II
- Allergic reaction against gabapentin and/or pregabalin
- History of recurrent hernia repair.
- Patient who has taken analgesia prior to the surgery
- Liver failure
- Renal failure
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Pregabalin Group Pregabalin The patient under Group P will be serving with 150 mg of oral Pregabalin 1 to 2 hours prior to induction.
- Primary Outcome Measures
Name Time Method Study is constructed to determine whether the use of oral pregabalin premedication to assess the analgesic efficacy for post operative pain at Alert, 15, 30, 45, 60 and 120 min, Day 1, Day 2 and Day 3. 3 days Efficacy: To compare the VAS score for pain after operation between the group at Alert, 15, 30, 45, 60 and 120 min, Day 1, Day 2 and Day 3.
- Secondary Outcome Measures
Name Time Method Opiod Sparing 3 days Total amount of rescue medication requires
Side effect of medication 3 days Severity of Post operative nausea and vomiting (PONV) graded with mild, moderare and severe(Vomiting) Side effect of medication includes headache, giddiness, visual disturbance, and difficulty in walking.
Trial Locations
- Locations (1)
University Malaya
🇲🇾Kuala Lumpur, Malaysia