Development of the Partial Pressure of Carbon Dioxide During 6-min Walking Test and at Night in Patients With Chronic Obstructive Pulmonary Disease IV
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 75
- Locations
- 1
- Primary Endpoint
- Increase of PaCO2 more than 5mmHg
Study Overview
Brief Summary
The aim of this study is to investigate the development of partial pressure of carbon dioxide during the 6-min walking test and during night in Chronic Obstructive Pulmonary Disease (COPD)-patients (GOLD stage IV). Therefore the partial pressure of carbon dioxide, oxygen saturation and the heart rate are registered by a device called "Sentec" during the mentioned periods. In addition a measurement of activity is realised by an activity monitor ("Sensewear").
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 30 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •COPD IV with and without a respiratory insufficiency
- •maximal paCO² of 55mmHg at admission (taken at rest by blood gas analysis without LTOT)
Exclusion Criteria
- •paCO² > 55mmHg
- •non-invasive ventilation
- •acute exacerbation
Arms & Interventions
exercise testing
6-minute walking test with pCO2 and pO2 measurement
Intervention: 6-minute walking test (Procedure)
Outcomes
Primary Outcomes
Increase of PaCO2 more than 5mmHg
Time Frame: From time of starting 6-minute walking test until the time of PaCO2-increase of more than 5mmHg assessed up to 6 minutes.
Secondary Outcomes
- Change of PaCO2(From the beginning of the 6-minute walking test until peak PaCO2, assessed up to 6 minutes)
Investigators
Klaus Kenn
Head physician (department of pneumology)
Schön Klinik Berchtesgadener Land