Ramipril and Hydrochlorothiazide Alone and in Combination for the Treatment of Essential Hypertension
- Conditions
- HypertensionBlood Pressure, High
- Registration Number
- NCT00355589
- Lead Sponsor
- Pfizer
- Brief Summary
The purpose of this study is to determine if there is greater blood pressure reduction using ramipril or hydrochlorothiazide alone or ramipril and hydrochlorothiazide together.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
- Previously diagnosed, or newly diagnosed essential hypertension. Blood pressure must be within a minimum and maximum range prior to drug treatment.
- Inability to discontinue all prior antihypertensive medications
- Heart failure
- History of stroke, myocardial infarction, or chest pain within 3 years, or an abnormal heart rhythm
- Liver or kidney disease
- Certain drugs used to treat other conditions like an enlarged prostate gland, or arthritis
- Allergy or reactions to certain medications used to treat high blood pressure
Other protocol-defined inclusion and exclusion criteria apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Compare the effects on sitting diastolic blood pressure of two antihypertensive drugs in combination against each antihypertensive alone after an eight week treatment period.
- Secondary Outcome Measures
Name Time Method Compare the effect on sitting diastolic blood pressure of two antihypertensive drugs in combination taken once daily against one antihypertensive drug taken twice daily. Compare the effect on sitting diastolic blood pressure of a dose of an antihypertensive drug taken once daily against half of the same dose taken twice daily. Compare the effect on the sitting and standing blood pressure among all treatment groups. Compare the safety of each medication regimen stated above. Compare the effect on mean 24-hour diastolic blood pressure (ABPM) of the medication regimens stated above.
Trial Locations
- Locations (60)
Cahaba Research Inc.
🇺🇸Birmingham, Alabama, United States
Clinical Research Associates
🇺🇸Huntsville, Alabama, United States
Pulmonary Associates
🇺🇸Glendale, Arizona, United States
Impact Clinical Trials
🇺🇸Beverly Hills, California, United States
Lovelace Scientific Resources, Inc.
🇺🇸Beverly Hills, California, United States
Associated Pharmaceutical Research Center, Inc.
🇺🇸Buena Park, California, United States
Marin Endocrine Care and Research
🇺🇸Greenbrae, California, United States
Memorial Research Medical Clinic
🇺🇸Long Beach, California, United States
The Intermed Group; Samaritan Medical Tower
🇺🇸Los Angeles, California, United States
National Research Institute
🇺🇸Los Angeles, California, United States
Scroll for more (50 remaining)Cahaba Research Inc.🇺🇸Birmingham, Alabama, United States