Ramipril and Hydrochlorothiazide Alone and in Combination for the Treatment of Essential Hypertension
- Conditions
- HypertensionBlood Pressure, High
- Registration Number
- NCT00355589
- Lead Sponsor
- Pfizer
- Brief Summary
The purpose of this study is to determine if there is greater blood pressure reduction using ramipril or hydrochlorothiazide alone or ramipril and hydrochlorothiazide together.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
- Previously diagnosed, or newly diagnosed essential hypertension. Blood pressure must be within a minimum and maximum range prior to drug treatment.
- Inability to discontinue all prior antihypertensive medications
- Heart failure
- History of stroke, myocardial infarction, or chest pain within 3 years, or an abnormal heart rhythm
- Liver or kidney disease
- Certain drugs used to treat other conditions like an enlarged prostate gland, or arthritis
- Allergy or reactions to certain medications used to treat high blood pressure
Other protocol-defined inclusion and exclusion criteria apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Compare the effects on sitting diastolic blood pressure of two antihypertensive drugs in combination against each antihypertensive alone after an eight week treatment period.
- Secondary Outcome Measures
Name Time Method Compare the effect on sitting diastolic blood pressure of two antihypertensive drugs in combination taken once daily against one antihypertensive drug taken twice daily. Compare the effect on sitting diastolic blood pressure of a dose of an antihypertensive drug taken once daily against half of the same dose taken twice daily. Compare the effect on the sitting and standing blood pressure among all treatment groups. Compare the safety of each medication regimen stated above. Compare the effect on mean 24-hour diastolic blood pressure (ABPM) of the medication regimens stated above.
Trial Locations
- Locations (60)
Lovelace Scientific Resources
🇺🇸Sarasota, Florida, United States
Partners in Primary Care
🇺🇸Voorhees, New Jersey, United States
Medford Medical Clinic Research Dept.
🇺🇸Medford, Oregon, United States
Philadelphia Health Associates
🇺🇸Philadelphia, Pennsylvania, United States
Medical Research Associates
🇺🇸Traverse City, Michigan, United States
Clinical Investigation Specialists, Inc.
🇺🇸Gurnee, Illinois, United States
Marin Endocrine Care and Research
🇺🇸Greenbrae, California, United States
Impact Clinical Trials
🇺🇸Beverly Hills, California, United States
Memorial Research Medical Clinic
🇺🇸Long Beach, California, United States
Lifespan Research Foundation
🇺🇸Miami, Florida, United States
Innovative Research of West Florida
🇺🇸Largo, Florida, United States
Renstar Medical Research
🇺🇸Ocala, Florida, United States
Metabolic Research Institute, Inc.
🇺🇸West Palm Beach, Florida, United States
Suncoast Clinical Research, Inc.
🇺🇸Palm Harbor, Florida, United States
Michigan Institute of Medicine
🇺🇸Livonia, Michigan, United States
Executive Health and Research Associates, Inc.
🇺🇸Atlanta, Georgia, United States
James R. Herron, MD, Ltd.
🇺🇸Chicago, Illinois, United States
WellMed Medical Management
🇺🇸San Antonio, Texas, United States
Advanced Biomedical Research of America
🇺🇸Las Vegas, Nevada, United States
Radiant Research - San Antonio
🇺🇸San Antonio, Texas, United States
Cahaba Research Inc.
🇺🇸Birmingham, Alabama, United States
The Intermed Group; Samaritan Medical Tower
🇺🇸Los Angeles, California, United States
Lovelace Scientific Resources, Inc.
🇺🇸Beverly Hills, California, United States
National Research Institute
🇺🇸Los Angeles, California, United States
Bayview Research Group
🇺🇸Studio City, California, United States
Cedar Crosse Research Center
🇺🇸Chicago, Illinois, United States
Midwest Institute for Clinical Research
🇺🇸Indianapolis, Indiana, United States
Sterling Research Group, Inc.
🇺🇸Cincinnati, Ohio, United States
Cumberland Research Assocites, LLC
🇺🇸Fayetteville, North Carolina, United States
The Lipid Center
🇺🇸Statesville, North Carolina, United States
Lion Research
🇺🇸Norman, Oklahoma, United States
Radiant Research - Mogadore
🇺🇸Mogadore, Ohio, United States
Punzi Medical Center
🇺🇸Carrollton, Texas, United States
MetaClin Research, Inc.
🇺🇸Austin, Texas, United States
Research Across America
🇺🇸Dallas, Texas, United States
Clinical Research Associates of Tidewater
🇺🇸Norfolk, Virginia, United States
Radiant Research - Tacoma
🇺🇸Lakewood, Washington, United States
Twin Cities Clinical Research
🇺🇸Brooklyn Center, Minnesota, United States
Smith Clinical Research
🇺🇸Marion, Ohio, United States
Pulmonary Associates
🇺🇸Glendale, Arizona, United States
Associated Pharmaceutical Research Center, Inc.
🇺🇸Buena Park, California, United States
Clinical Research Associates
🇺🇸Huntsville, Alabama, United States
Viking Clinical Research
🇺🇸Temecula, California, United States
Clinical Research of West Florida, Inc.
🇺🇸Clearwater, Florida, United States
University Clinical Research, Inc.
🇺🇸Pembroke Pines, Florida, United States
Triangle Medical Research Associates
🇺🇸Raleigh, North Carolina, United States
Unifour Medical Research Associates
🇺🇸Hickory, North Carolina, United States
SC Clinical Research Center, LLC
🇺🇸Columbia, South Carolina, United States
The Chase Wellness Center, Inc
🇺🇸Virginia Beach, Virginia, United States
Lyndhurst Gynecologic Associates, PA
🇺🇸Winston-Salem, North Carolina, United States
Piedmont Medical Research Associates
🇺🇸Winston-Salem, North Carolina, United States
Medical Research South
🇺🇸Charleston, South Carolina, United States
Clinical Research of South Florida
🇺🇸Coral Gables, Florida, United States
South Florida Clinical Research Center
🇺🇸Hollywood, Florida, United States
Radiant Research - Greer
🇺🇸Greer, South Carolina, United States
International Research Associates, LLC
🇺🇸Miami, Florida, United States
Sun Coast Clinical Research
🇺🇸New Port Richey, Florida, United States
University of Connecticut Health Center
🇺🇸Farmington, Connecticut, United States
University Clinical Research Deland, Inc.
🇺🇸Deland, Florida, United States
Clinical Trials Research
🇺🇸Roseville, California, United States