Behavioral and Neuroimaging Changes After Cognitive Rehab in TBI and MCI

VA Office of Research and Development1 site in 1 country82 target enrollmentJuly 2008

ConditionsMild Cognitive Impairment Alzheimer's Disease Traumatic Brain Injury

Overview

Phase: Phase 1
Intervention: Not specified
Conditions: Mild Cognitive Impairment
Sponsor: VA Office of Research and Development
Enrollment: 82
Locations: 1
Primary Endpoint: Memory Test Accuracy on Trained Stimuli
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Memory deficits are common after traumatic brain injuries (TBI) and are characteristic of various forms of dementia, such as Alzheimer's disease and its common precursor mild cognitive impairment (MCI). This project intends to assess the efficacy of cognitive rehabilitation in these patient populations. We will also use neuroimaging (functional magnetic resonance imaging - fMRI) to assess changes in brain activity that occur following cognitive rehabilitation.

Registry

clinicaltrials.gov

Start Date

July 2008

End Date

September 2014

Last Updated

9 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

VA Office of Research and Development

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•General inclusion criteria (all patients):
•A minimum of 12 years of education or attainment of a Graduation Equivalency Diploma;
•All medications stable for approximately 3 months;
•No history of severe mental illness;
•No current untreated alcohol or substance abuse/dependence;
•English as native and preferred language;
•MRI-compatible if taking part in fMRI studies 7) Able to give informed consent.
•MCI Inclusion Criteria:
•Diagnosis of amnestic MCI based on criteria set forth by Petersen (2004). Additionally, other potential causes of cognitive deficit ruled out by the referring physician;
•55 years of age or older.