Comparative Study of Subcision Followed by Diluted Calcium Hydroxylapatite Injection Versus Subcision Followed by Painting CROSS TCA Technique for the Treatment of Atrophic Acne Scars
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Patient satisfaction
研究概览
简要总结
This study aimed to compare the safety and efficacy of subcision followed by diluted calcium hydroxyapatite injection versus subcision followed by the painting original chemical reconstruction of skin scars (CROSS) technique using trichloroacetic acid (TCA) for the treatment of atrophic acne scars.
详细描述
Atrophic scars present as depressions secondary to fibrous contractions. Subcision is a technique in which a needle is inserted under the acne scar to sever the fibrous tissue (tethers) that bind down the scar. This releases the fibrous tissue.
The original chemical reconstruction of skin scars (CROSS) technique using trichloroacetic acid (TCA) entails focal application of highly concentrated TCA (70% to 100%) with firm pressure applied to the entire atrophic area using a sharpened wooden applicator until frosting occurs.
Fillers containing hyaluronic acid, calcium hydroxyapatite, and poly-L-lactic acid are increasingly used to correct atrophic acne scarring as they augment soft tissue in variable degree and are most effective in soft rolling or boxcar scars.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 20 to 50 years.
- •Both sexes.
- •Patients with atrophic acne scars.
排除标准
- •Patients with Fitzpatrick skin phototypes V and VI.
- •Receiving systemic isotretinoin medication at the time of the study.
- •Active bacterial, viral or fungal infections in the treatment area.
- •Hypertrophic scarring or keloidal tendency.
- •Photosensitivity or photodermatitis.
- •Unrealistic expectation, bleeding, coagulation disorders, and any other related skin disease.
- •Pregnant or lactating females.
- •Chronic debilitating diseases such as diabetes mellitus, cardiovascular diseases, renal failure, hepatic diseases, chronic respiratory diseases or any endocrine diseases.
- •History of immunosuppressive drug intake or chemotherapy within 6 months before treatment.
研究组 & 干预措施
Study group
Patients with atrophic acne scars.
干预措施: Calcium hydroxylapatite filler (Drug)
Study group
Patients with atrophic acne scars.
干预措施: Painting chemical reconstruction of skin scars trichloroacetic acid technique (Drug)
结局指标
主要结局
Patient satisfaction
时间窗: One week
Patient satisfaction was assessed at the final follow-up visit using a 5-point Likert-type scale, comparing outcomes to the pre-treatment condition. The scale ranged from 1 (highly dissatisfied), 2 (slightly dissatisfied), 3 (neither satisfied nor dissatisfied), 4 (satisfied), to 5 (highly satisfied).
次要结局
未报告次要终点
研究者
Riham Mohamed ElSayed ElSetiha
Resident of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Tanta University