Comparing paracetamol and tramadol for pain control in acute pancreatitis

Phase 1

Not yet recruiting

• Conditions: Health Condition 1: K852- Alcohol induced acute pancreatitis

• Registration Number: CTRI/2022/05/042361
• Lead Sponsor: AIIMS Bhubaneswar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 30 May 2022

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Patients with AP diagnosed as per the revised Atlanta classification

Abdominal pain at enrollment

Hospitalization within 7 days of onset of pain

Patients who are willing to give consent

Exclusion Criteria

Age <18 years or >75 years

Patients with grade 2 organ failure at enrollment as defined by modified Marshall grading

Patients with known coronary artery disease

Patients in altered sensorium

Patients with a serum creatinine > 1.5 mg/dL

Patients with evidence of chronic pancreatitis

Patients with past history of allergy to tramadol or paracetamol

Patients with suspected pancreatic carcinoma

Refusal to give consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The difference in the efficacy of paracetamol and tramadol for pain relief was the primary outcome, which was measured by the total dose of <br/ ><br>pentazocine required as the rescue analgesic, pain-free period, and the total <br/ ><br>number of demands of the rescue analgesicTimepoint: The study will end at 50 hours, i.e., 2 hours after the last dose of the analgesic

Secondary Outcome Measures

Name	Time	Method
Difference in the adverse events between the 2 groups will be the secondary outcomeTimepoint: The study will end at 50 hours, 2 hours after the last dose of the analgesic