Diet and Its Relationship With Couple Infertility

Recruitment & Eligibility

Inclusion Criteria

Common to both infertile and fertile couples:

Couples where both members are over eighteen and at childbearing age (≤38 for women and ≤ 45 for men)
Couples where both members agreed to take part in the study
Couples where both members completed a medical check-up and gave an informed consent. Infertile couples could be included following a medical consultation for infertility
Couples with none of its member facing any comprehension difficulty in oral or written French language
Couples where both members are affiliated to the French NHS [national health service] (beneficiary or legal claimant)

Specific to fertile couples:

fertile couples who naturally and spontaneously conceived a or many children with a time to conceive shorter than 12 months.

Specific to infertile couples:

Infertile couples (primary, infertility, inability to conceive a child after 12 months of unprotected sexual intercourse)
Couples where the male partner has sperm parameters compatible with a natural conception
Couples where the female partner does not present anovulation, ovarian insufficiency and or any uterus-tubal pathology

Exclusion Criteria

Common to both infertile and fertile couples:

couples where one of the members is under eighteen or not a childbearing age (>38 for women an >45 for men)
couples where at least one member refused to give written agreement for the study
couples where at least one member shows any known cardiovascular risk (diabetes, hypercholesterolemia, HBR)
couples where at least one member shows any known cardiovascular pathology, digestive pathology, no good absorptive pathology or a cancer
couples where at least one member faces some difficulty in understanding French language
couples where at least one member is not affiliated with the French NHS (beneficiary or legal claimant)

Specific to fertile couples:

•Couples where the woman had a miscarriage or medical termination of pregnancy with current partner

Specific to infertile couples:

Couples in which it is not the first pregnancy
Couples with the male member showing either:
- severe oligozoospermia (<5 millions/ml) or a confirmed azoospermia (absence of spermatozoid in the ejaculate)
- a moderate non idiopathic oligozoospermia (5-20 millions/ml), related to one more of the following factors:
  1. toxic (chemotherapy, radiotherapy, drugs with a demonstrated effect on spermatogenesis)
  2. infectious
  3. anatomic: vasectomy, congenital anomaly (agenesis of vas deferens), long post-traumatic ischemia
  4. endocrine: hypogonadotropic, hypogonadism
  5. cytogenetic: klinefelter syndrome, translocation
couples whose male partner shows an abnormality of the male genital tractus : VARICOCEME undescended,testis, testicular volume < 12ml
couples whose female partner presents an anovulation, ovarian insufficiency or a proven uterus-tubal pathology

Study & Design

Primary Outcome Measures

Name	Time	Method
Evaluate the nutritional status of fertile and infertile couples (food questionnaire - biologic, anthropometric and clinical balance).	24 hours

Secondary Outcome Measures

Name	Time	Method
Impact of genetic polymorphism on clinical and biological phenotypes linked to food behaviour in infertility context (MTHFR polymorphism for folates metabolism)	12 months
Pregnancy and obstetrical pathologies, prematurity, twin birth, weight of the new-born in infertile couples	in the 6 months
Impact of lifestyle (alcohol and tabacco consumption, physical activity, anxiety and sleep) on diet and fertility	24 hours
ART parameters, if appropriate	in the 6 months
Impact of nutritional status on fertility and ART parameters	24 hours
Fertility : time to pregnancy (TTP)	in the 6 months
Male infertility : quantitative or qualitative semen abnormalities	in the 6 months

Recruitment & Eligibility