Food Lifestyle and Fertility Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 54
- 试验地点
- 2
- 主要终点
- Endocrine, metabolic biomarkers and proteins and Fertility outcome parameters
研究概览
简要总结
In vitro fertilization (IVF) is an assisted reproductive technique to achieve pregnancy in subfertile couples of which the average success rate is only 25%. Mild ovarian stimulation treatment yields less oocytes, has less adverse effects but has a comparable clinical outcome compared to conventional stimulation treatment. There is high inter- and intra person variability in ovarian response and fertility outcome parameters after stimulation treatment and little is known about explanatory variables herefore.
Nutrition and in particular folate, or its synthetic derivative folic acid, is a B-vitamin which has been widely asssociated with reproductive outcome and subfertility. Therefore, in this study we aim to investigate the influence of preconception nutrition and folic acid use on ovarian response after mild/conventional stimulation treatment and to identify biomarkers in the follicular fluid which can indicate oocyte quality and other fertility outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- — 至 37 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All couples with an indication for IVF/ICSI treatment in the Erasmus Medical Center
排除标准
- •Prior oocyte donation
- •Endometriosis
- •Hydrosalpinx
- •MESA/PESA
- •BMI <18 or >29kg/m2
- •Menstrual cycle disruptions
- •Indication for Intra Cytoplasmic Sperm Injection (ICSI)
- •Prior IVF treatment without embryo transplant
- •History of recurrent abortion
- •Abnormal karyotype of male/female
- •Uterine abnormalities
结局指标
主要结局
Endocrine, metabolic biomarkers and proteins and Fertility outcome parameters
时间窗: At menstrual cycle day 2 before stimulation, on the day of hCG administration after stimulation treatment and after embryo transplantation
次要结局
- Homocysteine-methionine cycle biomarker, endocrine and folate levels in serum(At menstrual cycle day 2 before stimulation and on the day of hCG administration after stimulation treatment)