Biomarkers in the Evaluation of Chronic Lung Disease

Completed

• Conditions: Pulmonary Arterial Hypertension; Interstitial Lung Disease; Pulmonary Hypertension
• Interventions: Other: Blood Gas; Other: Pulmonary Exercise Test; Other: Spirometry; Other: Breath Condensate Collector

• Registration Number: NCT00926523
• Lead Sponsor: Northwell Health

Brief Summary

We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a useful biomarker of the severity and progression of both ILD and PH.

Detailed Description

We hypothesize that hypoxia-induced pulmonary vascular remodeling is mediated by macrophage migration inhibitory factor (MIF), that remodeling is in fact the reflection of a chronic inflammatory process, and that MIF may be a useful biomarker of the severity and progression of both ILD and PH.

To study this hypothesis, we have two specific aims:

1. To evaluate plasma MIF concentration as a marker of severity in ILD and PH and

2. To determine the utility of breathe condensate analysis in the evaluation of ILD and PH. If we are successful in identifying MIF as a biomarker, it may identify MIF as a useful therapeutic target, as we have shown in other inflammatory disorders.

Study Timeline

• Study Start: 2009-06
• Study First Submitted: 2009-06-19
• Study First Submitted QC: 2009-06-19
• Study First Posted: 2009-06-23
• Primary Completion: 2011-03
• Study Completion: 2011-03
• Status Verified: 2011-05
• Last Update Submitted: 2011-05-26
• Last Update Posted: 2011-05-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 67

Inclusion Criteria

• Subject are at least 18 years of age
• Subject has confirmed Pulmonary Hypertension and Interstitial Lung Disease
• Subject are able to complete study procedures, such as spirometry, and Pulmonary Exercise test.

Exclusion Criteria

• Subject are pregnant
• Subject is unable to perform tasks associated with study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Affected	Spirometry	Subjects have Pulmonary Hypertension
Healthy Controls	Blood Gas	Subjects are made up of healthy adults
Healthy Controls	Pulmonary Exercise Test	Subjects are made up of healthy adults
Healthy Controls	Spirometry	Subjects are made up of healthy adults
Affected	Blood Gas	Subjects have Pulmonary Hypertension
Affected	Pulmonary Exercise Test	Subjects have Pulmonary Hypertension
Affected	Breath Condensate Collector	Subjects have Pulmonary Hypertension
Healthy Controls	Breath Condensate Collector	Subjects are made up of healthy adults

Trial Locations

Locations (1)

Interstitial Lung Disease and Pulmonary Hypertension Programs; 🇺🇸 New Hyde Park, New York, United States