Saliva Levels of S100A12, CRP, Fetuin-A in Periodontal Disease Patients
- Conditions
- Periodontal Inflammation
- Interventions
- Diagnostic Test: salivary samples
- Registration Number
- NCT03345745
- Lead Sponsor
- T.C. ORDU ÜNİVERSİTESİ
- Brief Summary
Hs-CRP, Fetuin-A and S100A12 are acute phase proteins associated with many systemic diseases and conditions. The aim of this study was to determine the clinical parameters and salivary Hs-CRP, Fetuin-A and S100A12 levels before and after non-surgical periodontal treatments in the patients with periodontal diseases.
A total of 54 subjects were divided in to three groups; periodontally healthy (n: 18), gingivitis (n: 18), chronic periodontitis (n: 18). Clinical periodontal parameters, salivary Hs-CRP, Fetuin-A and S100A12 levels and salivary flow rates were evaluated at baseline and a month after the treatments. Salivary Hs-CRP, Fetuin-A and S100A12 levels were assayed by ELISA.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 54
never-smokers no history of systemic disease no patients had been under periodontal therapy and medicine for at least 6 months before the study no pregnancy or lactation no alcohol or antioxidant vitamin consumption.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Gingivitis patients salivary samples Salivary samples Periodontally healthy subjects salivary samples Salivary samples Chronic periodontitis patients salivary samples Salivary samples
- Primary Outcome Measures
Name Time Method Salivary acute phase proteins Baseline C-Reactive Protein
- Secondary Outcome Measures
Name Time Method Evaluating periodontal health Baseline - a month after the periodontal treatments gingival bleeding on probing
Trial Locations
- Locations (1)
Ordu University
🇹🇷Ordu, Turkey