Serum Hs-CRP in Periodontitis Patients With or Without Diabetes

Not Applicable

Completed

• Conditions: Periodontal Disease; Diabetes Mellitus, Type 2
• Interventions: Procedure: Scaling and root planing

• Registration Number: NCT03908606
• Lead Sponsor: Cairo University

Brief Summary

the aim of this study was to assess serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal therapy.

Detailed Description

Periodontitis and diabetes are chronic disorders with a two-way correlation as they can both stimulate an inflammatory response with subsequent formation of inflammatory mediators and cytokines. C reactive protein is an inflammatory plasma marker having a role in the systemic reaction to inflammation. thus, our aim in the current study was to evaluate serum levels of high sensitivity c reactive protein in periodontitis patients with and without type 2 diabetes in a trial to analyze its prognostic effect following non-surgical periodontal therapy. A total of 60 patients were enrolled in this study. ELISA was used for determination of hs- CRP. Non- surgical periodontal therapy was carried out for all periodontitis patients.

Study Timeline

• Study Start: 2018-04-11
• Primary Completion: 2019-01-02
• Study Completion: 2019-01-02
• Status Verified: 2019-04
• Study First Submitted: 2019-04-06
• Study First Submitted QC: 2019-04-08
• Last Update Submitted: 2019-04-08
• Study First Posted: 2019-04-09
• Last Update Posted: 2019-04-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Diabetic patients type 2
2. Periodontitis patients

Exclusion Criteria

1. Smokers
2. Pregnant females

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Periodontitis patients with diabetes type 2	Scaling and root planing	scaling and root planing was administered to all patients. Serum samples were collected before and after treatment to assess hs-CRP levels. Glycated hemoglobin was measured before and after treatment
Periodontitis patients	Scaling and root planing	scaling and root planing will be done to periodontitis patients. Serum samples were collected before and after treatment to assess hs-CRP levels.

Primary Outcome Measures

Name	Time	Method
clinical attachment level	3 months	gain in clinical attachment level

Trial Locations

Locations (1)

Cairo University; 🇪🇬 Cairo, Egypt