Efficacy of intravenous crystalloid coload plus ephedrine to prevent post spinal hypotension in parturient undergo elective cesarean section: A prospective randomized controlled trial

Phase 4

Recruiting

• Conditions: Parturients 18 - 40 year undergoing elective caesarean section under spinal anesthesia postspinal hypotension after spinal anesthesia until delivery; Cesarean section; Crystalloid; Ephedrine; Hypotension; Spinal anesthesia

• Registration Number: TCTR20210917005
• Lead Sponsor: Faculty of medicine, Khon Kaen University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-17
• Study Completion: 2022-07-15
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

Inclusion criteria
Parturients aged 18 - 40 year old
Singleton pregnancy ,GA 37-42 week
ASA II

Exclusion Criteria

Exclusion criteria
Refuse to participate the project
BW < 50 kg
History of chronic hypertension or Pregnancy induced hypertension
Maternal medical morbidity (cardiovascular,cerebrovascular,
chronic disease)
contraindication to ephedrine drug

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Maternal hypotension After intrathecal injection of local anesthesia until delivery Repeat blood pressure every 2.5min until delivery

Secondary Outcome Measures

Name	Time	Method
intra-operative rescue inotropic drug After intrathecal injection of local anesthesia until delivery Dose of rescue inotropic drug,symptomatic of maternal nausea & vomiting After intrathecal injection of local anesthesia until delivery Episode of symptomatic of maternal nausea & vomiting ,maternal tachycardia After intrathecal injection of local anesthesia until delivery Repeat heart rate every 2.5min until delivery,Apgar scores at the first and fifth minutes After delivery Measurement of Apgar scores at the first and fifth minutes