A study comparing two groups of patients undergoing bilateral total knee replacement one receiving only injection dexamethasone and other receiving injection levosulpiride with injection dexamethasone to assess the effect for post operative nausea and vomiting prophylaxis.
- Conditions
- Health Condition 1: M170- Bilateral primary osteoarthritis of kneeHealth Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2023/08/056491
- Lead Sponsor
- Dr Sunny Rupal
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Patients scheduled for bilateral knee replacement surgery of ASA grade 1 and 2 , for degenerative joint disease.
2. Patients with APFEL score of at least 1 or more.
ASA III, IV patients with severe illness
2. Patients with history of severe valular heart disease, vascular or conduction abnormalities
3. Known history of allergy to the study drugs
4. Any contraindication to spinal anesthesia or failure of spinal anesthesia necessitating general anesthesia
5. Patients with neurologic or cognitive disorders/ non cooperative patients/ patients with psychosis.
6. Patients with poor glycemic control HBA1c >8.
7. Severe hepatic or renal dysfunction
8. Intake of anti-emetics or steroids within last 24 hours of surgery
9. Patientâ??s refusal
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of PONV <br/ ><br> Incidence of nausea <br/ ><br> Incidence of vomiting <br/ ><br>2. Complete response of study drug (no nausea or vomiting or need of rescue drugs)Timepoint: Till 24 hours
- Secondary Outcome Measures
Name Time Method Time of onset <br/ ><br>Time of severity & duration of PONV <br/ ><br>Severity of nausea <br/ ><br>Severity of vomiting <br/ ><br>Number of rescue antiemetic drugs requirements <br/ ><br>Pain assessment <br/ ><br>Side effects if anyTimepoint: Till 24 Hours