Feasibility Study of Prostate Tumor Localization for Focal Cryoablation of Prostate Carcinoma

Not Applicable

Terminated

Brief Summary: The purpose of the present study is to find out if MRI techniques examining (1) the motion of water molecules in the prostate (diffusion sensitive MRI), (2) the difference in blood flow to the prostate (dynamic contrast enhanced MRI), and (3) differences in chemical composition of the prostate (MR spectroscopy), can be used to detect prostate cancer early and non-invasively. Localization of the cancer within the prostate would be of particular importance in focal cryoablation of prostate carcinoma which we hope to improve as a result of this project.

Additional aim of the study is to correlate expression of genes believed to pay a role in prostate cancer with MRI findings.

Detailed Description: Radical prostatectomy patients will undergo an MRI prior to their scheduled surgery. Ex vivo imaging will be done on prostates once removed. Results from the final pathology with be compared with results of imaging to determine the accuracy of the image analysis in cancer localization and staging.

Brachytherapy patients will undergo an MRI prior to their scheduled procedure. Two areas of suspected cancer and two areas without suspected cancer will be prospectively identified based on the MRI imaging. At the time of brachytherapy, transrectal needle biopsies will be obtained from the previously identified areas. The needle cores will be reviewed by study pathologist to determine the accuracy of the image analysis in cancer localization and staging.

Recruitment & Eligibility

Inclusion Criteria

patients who have been diagnosed with prostate cancer and are scheduled for radical prostatectomy or for brachytherapy
patients who have not received any preoperative treatment for their diagnosis of prostate cancer

Exclusion Criteria

patients with implants that are electronically, magnetically, or mechanically active
patients with intracranial aneurysm clips
patients who have undergone cosmetic eyelid surgery
patients with history of pheochromocytoma, insulinoma and acute glaucoma
patients with estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2

Arm && Interventions

Group	Intervention	Description
Brachytherapy patients	MRI scan	Patients who have been diagnosed with prostate cancer and are scheduled to undergo brachytherapy and have not received any preoperative treatment for prostate cancer.
Radical prostatectomy patients	MRI scan	Patients who have been diagnosed with prostate cancer and are scheduled to undergo radical prostatectomy and have not received any preoperative treatment for prostate cancer.

Primary Outcome Measures

Name	Time	Method
Improved Accuracy of Prostate Cancer Detection by MRI Scan.	At time of treatment	Data obtained as part of this study could not be analyzed in a meaningful way due to problems with correlation between the cancerous tissue identified by histology and tissue imaging from imaging.

Secondary Outcome Measures

Name	Time	Method
Successful MRI Guidance of Transrectal Ultrasound Biopsy in Patients.	At time of treatment	Ultrasound guidance of transrectal ultrasound biopsy was not attempted.