Effect of curcumin on the prevention of contrast induced nephropathy
- Conditions
- ephropathy induced by contrast agents.Nephropathy induced by other drugs, medicaments and biological substancesN14.1
- Registration Number
- IRCT20210413050958N2
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 227
All subjects who receive IV. contrast agent (except renal artery angiography candidates)
Hepatic failure (Child-Pugh Score B or C)
Biliary obstruction
End-stage renal insufficiency (eGFR less than 15 mL/min)
Acute renal insufficiency (BUN/Creatinine more than 20)
A history of reaction to contrast media
Taking potentially nephrotoxic medicines (48 h before and 24 h after the procedure)
Pulmonary oedema
Gastrointestinal disorders (such as diarrhea, vomiting, dehydration, bleeding, malabsorption, indigestion, etc.)
Multiple myeloma
Exposure to contrast media within 7 days before the procedure
Pregnancy
Taking N-acetyl cysteine, teofiline, dopamine, fenoldopam, manitol, and NaHCO3 within 48 h before coronary angiography.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Increased serum creatinine level. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Creatinine kit.
- Secondary Outcome Measures
Name Time Method Blood urea nitrogen. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Blood urea nitrogen kit.;Cell blood count. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Sysmex Cell Counter.;Creatinin. Timepoint: Before the intervention and 48 hours after contrast agent injection. Method of measurement: Serum creatinin kit.