Posttraumatc headache - pain related evoked potentials and conditioned pain modulation as possible biomarkers for the identification of risk patients
- Conditions
- G44.3Chronic post-traumatic headache
- Registration Number
- DRKS00023623
- Lead Sponsor
- eurologische KlinikBG Universitätsklinikum Bergmannsheil gGmbH
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 46
Inclusion criteria for patients:
- Acute or persistent headache resulting from a traumatic head injury
- The headache developed within 7 days of any of the following: the head injury, regaining consciousness after the head injury, discontinuation of medication that interferes with the ability to feel or report a headache after the head injury
- The headache is not better explained by another ICHD-3 diagnosis
Inclusion criteria for healthy control subjects:
- none of the exclusion criteria is met
- Present declaration of consent
- No abnormal result in the questionnaire or physical examination
- no use of drugs with peripheral or central nervous effects /side effect
- no neurological or psychiatric illness
Exclusion criteria for patients:
- Age <18 years
- no declaration of consent
- Average pain intensity in the last 4 weeks <2 (NRS 0-10)
- Current pain intensity <2 (NRS 0-10)
- Insufficient knowledge of German or other communication problems
- Neuropathic pain syndromes
- Headache illness known before the accident
- Treatment with topical local anesthetics for <7 days in the last 6 weeks or for >7 days in the last 4 months
- Treatment with topical capsaicin in the past 6 months
- Epilepsy treated with anticonvulsants
- Psychiatric illness treated with anticonvulsants or antidepressants with a proven effect on neuropathic pain
- Other pain localization with a pain intensity =6 (NRS 0-10) on =15 days / month
- Other severe systemic or focal CNS affection
- Other central or peripheral neurological disorders
- peripheral arterial occlusive disease (except for stage Fontaine I)
- Serious cognitive or psychiatric impairment
Exclusion criteria for healthy control subjects:
- Age <18 years
- no declaration of consent
- Average pain intensity in the last 4 weeks> 2 (NRS 0-10)
- Current pain intensity >0 (NRS 0-10)
- Insufficient knowledge of German or other communication problems
- Neuropathies, radiculopathies, or nerve lesions
- Chronic pain syndromes
- Treatment with topical local anesthetics for the past 6 weeks
- Treatment with topical capsaicin in the past 6 months
- Epilepsy treated with anticonvulsants
- Psychiatric illness treated with anticonvulsants or antidepressants with a proven effect on neuropathic pain
- Other severe systemic or focal CNS affection
- Other central or peripheral neurological disorders
- peripheral arterial occlusive disease (except for stage Fontaine I)
- Serious cognitive or psychiatric impairment
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1) Amplitude height of the PREP of patients with posttraumatic headache compared with healthy control group<br>2) Height of the CPM effect based on the pain intensity compared to the control group<br>3)Height of the CPM effect based on the stimulus amplitude compared to the control group
- Secondary Outcome Measures
Name Time Method 4) correlation between headache intensity and PREP amplitude<br>5) correlation between headache intensity and CPM effect<br>6) correlation between headache duration and CPM effect difference compared to control group