The Relationship Between the Tumor Markers and Interstitial Lung Disease

Completed

• Conditions: the Relationship Between the Tumor Markers and Interstitial Lung Disease Patients
• Interventions: Other: No Intervention

• Registration Number: NCT04597814
• Lead Sponsor: The First Affiliated Hospital of Guangzhou Medical University

Brief Summary

The serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), CA125 are often increased in interstitial lung disease patients.

This study was undertaken to investigate the source of these serum tumor markers.

Detailed Description

The serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), CA125 are often increased in interstitial lung disease patients.

This study was undertaken to investigate the source of these serum tumor markers.We hypothesis that these tumor markers are released from the lung.

The broncholveolr lvge fluid levels of carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), CA125 were measured in the interstitial lung disease patients before lung transplantation. The immunohistochemical test was performed in the specimen lung after lung transplantation.

Study Timeline

• Study Start: 2019-01-01
• Status Verified: 2020-10
• Primary Completion: 2020-10-15
• Study Completion: 2020-10-15
• Study First Submitted: 2020-10-16
• Study First Submitted QC: 2020-10-16
• Study First Posted: 2020-10-22
• Last Update Submitted: 2020-10-22
• Last Update Posted: 2020-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

Not provided

Exclusion Criteria

1. tumor
2. Interstitial lung disease patients could not be performed by lung transplantation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
interstitial lung disease patients	No Intervention	interstitial lung disease patients who need lung transplantation
non- interstitial lung disease patients	No Intervention	non- interstitial lung disease patients who need thoracic surgery to remove pneumatocele

Primary Outcome Measures

Name	Time	Method
serum levels of carcinoembryonic antigen (CEA)	6months	serum levels of carcinoembryonic antigen (CEA)
serum levels of carbohydrate antigen 19-9 (CA19-9)	6months	serum levels of carbohydrate antigen 19-9 (CA19-9)
The alveolar lavage fluid levels of carbohydrate antigen 19-9 (CA19-9)	1 week	The alveolar lavage fluid levels of carbohydrate antigen 19-9 (CA19-9)
The alveolar lavage fluid levels of carbohydrate antigen 125	1 week	The alveolar lavage fluid levels of carbohydrate antigen 125
serum levels of carbohydrate antigen 125(CA125)	6months	serum levels of carbohydrate antigen 125(CA125)
The alveolar lavage fluid levels of carcinoembryonic antigen (CEA)	1 week	The alveolar lavage fluid levels of carcinoembryonic antigen (CEA)
The lung tissue levels of carcinoembryonic antigen (CEA)	1 week	The lung tissue levels of carcinoembryonic antigen (CEA)
The lung tissue levels of carbohydrate antigen 19-9 (CA19-9)	1 week	The lung tissue levels of carbohydrate antigen 19-9 (CA19-9)
The lung tissue levels of carbohydrate antigen 125	1 week	The lung tissue levels of carbohydrate antigen 125

Trial Locations

Locations (1)

The First Affiliated Hospital of Guangzhou Medical University; 🇨🇳 Guangzhou, Guangdong, China