Acute Effects of High Impact Exercise on Bone Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Serum sclerostin concentration
研究概览
简要总结
The goal of this study is to investigate the acute effects of drop-landing exercise on the bone metabolism biomarkers and extracellular vesicles in healthy young males, in order to gain a deeper understanding of the mechanotransduction mechanisms involved in bone metabolism.
The main question aims to answer:
• Does a single bout acute drop-landing exercise change serum sclerostin, other bone signaling markers, and circulating extracellular vesicles levels?
Participants complete both the drop-landing and control trials in a randomized order, with a minimum washout period of one week between trials. During each trial, blood samples are collected at three time points: pre-, immediately post, and 1-hour post drop-landing/control exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18-35 years old
- •Body mass index (BMI) of 18.5-29.9
- •Can understand and follow trial instructions
排除标准
- •Have any uncontrolled cardiovascular or respiratory disease
- •Have severe musculoskeletal or neurological disease likely to affect ability to perform an exercise
- •Have medical conditions known to affect musculoskeletal health
- •Have medications known to affect bone metabolism (e.g., corticosteroids, thyroxine, antiepileptic, and antiretroviral agents)
- •Regular (more than once per week) participation in high-intensity resistance or impact-type exercise in the past 6 months
- •Current smoker or vaper
结局指标
主要结局
Serum sclerostin concentration
时间窗: Blood samples are collected at pre- (baseline), immediately post, 1-hour post drop-landing/control exercise in main trials.
Serum sclerostin concentration is quantified using an enzyme-linked immunosorbent assay (ELISA) and reported in picograms per milliliter (pg/mL).
次要结局
- Serum dickkopf Wnt signaling pathway inhibitor 1 (DKK1) concentration(Blood samples are collected at pre- (baseline), immediately post, 1-hour post drop-landing/control exercise in main trials.)
- Serum osteoprotegerin (OPG) concentration(Blood samples are collected at pre- (baseline), immediately post, 1-hour post drop-landing/control exercise in main trials.)
- Serum irisin concentration(Blood samples are collected at pre- (baseline), immediately post, 1-hour post drop-landing/control exercise in main trials.)
- Circulating extracellular vesicle (EV) particle concentration and size(Blood samples are collected at pre- (baseline), immediately post, 1-hour post drop-landing/control exercise in main trials.)
- Ground reaction force during drop-landing exercise(Ground reaction force is recorded during each drop-landing exercise.)
研究者
Katherine Brooke-Wavell
Professor
Loughborough University