NL-OMON39817
已完成
2 期
Boosting oxytocin after trauma: The effects of intranasal oxytocin administration on emotional and motivational brain processes in PTSD - The effect of oxytocin in PTSD
概览
- 阶段
- 2 期
- 干预措施
- 未指定
- 疾病 / 适应症
- posttraumatic stress disorder (PTSD) and stress disorder
- 发起方
- Academisch Medisch Centrum
- 入组人数
- 83
- 状态
- 已完成
- 最后更新
- 去年
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •\* Age 18 \* 65 years
- •\* Capable to read and comprehend the Dutch language
- •\* Eligibility for MRI (i.e. no metals, pacemakers or claustrophobia)
- •\* Exposed to a potentially traumatic event, according to PTSD A1 criterion in the DSM\-IV (minimal 1 month ago), quantified as a score of 1 or higher on the Life Events Checklist (LEC).
- •PTSD patients:
- •\* Current PTSD diagnosis
- •\* CAPS score \* 45
- •Traumatized healthy controls:
- •\* CAPS\-score \< 15
排除标准
- •\* Any severe or chronic systemic disease
- •\* Current psychotic, bipolar, substance\-related, severe personality disorder, or mental retardation
- •\* Current severe depressive disorder
- •\* Prominent current suicidal risk or homicidal ideation
- •\* Severe cognitive impairment or a history of organic mental disorder
- •\* History of neurological disorders (e.g., traumatic brain injury, seizure history)
- •\* Reports of ongoing traumatization (e.g., in case of partner violence as index adult trauma)
- •\* Evidence of clinically significant and unstable medical conditions in which OT administration is contra\-indicative such as cardiovascular, gastro\-intestinal, pulmonary, severe renal, endocrine or hematological disorders, glaucoma, history of epilepsy, or a stroke or myocardial infarction within the past year
- •\* Use of certain medication: prostaglandins, certain anti\-migraine medications (ergot alkaloids), ß\-adrenergic receptor\-blocking agents, systemic glucocorticoids and psychopharmacological medication.
- •\* Sensitivity or allergy for OT or its components (e.g. methylhydroxybenzoate and propylhydroxybenzoate)
结局指标
主要结局
未指定
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