Effect of Escalating Doses of a Novel Viscous Polysaccharide on Postprandial Glycemia
Phase 2
Completed
- Conditions
- Blood Glucose, Postprandial
- Interventions
- Dietary Supplement: ControlDietary Supplement: Second ControlDietary Supplement: PolyGlycopleX (PGX)Dietary Supplement: PolyGlycopleX (PG)Dietary Supplement: PolyGlycopleX
- Registration Number
- NCT00801814
- Lead Sponsor
- Glycemic Index Laboratories, Inc
- Brief Summary
To determine palatability and extent to which escalating doses of a novel highly viscous polysaccharide \[NVP\] reduces postprandial glycemia when added to a liquid and a solid meal.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- healthy individuals
- 18-75 years old
- BMI less than 35 kg/m2
Exclusion Criteria
- Medications influencing gastrointestinal function
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 3 Control Glucose drink control 1 Control White Bread 2 Second Control White Bread and Margarine Control 4 PolyGlycopleX (PGX) White bread and margarine or Glucose drink 4 PolyGlycopleX (PG) White bread and margarine or Glucose drink 4 PolyGlycopleX White bread and margarine or Glucose drink 5 PolyGlycopleX (PGX) White bread and margarine or Glucose drink 5 PolyGlycopleX (PG) White bread and margarine or Glucose drink 5 PolyGlycopleX White bread and margarine or Glucose drink 6 PolyGlycopleX (PGX) White bread and margarine or Glucose drink 6 PolyGlycopleX (PG) White bread and margarine or Glucose drink 6 PolyGlycopleX White bread and margarine or Glucose drink
- Primary Outcome Measures
Name Time Method postprandial glycemia Acute study measuring postprandial glucose levels over 2 hours
- Secondary Outcome Measures
Name Time Method The glucose reduction index potential (GRIP). The GRIP factor is the reduction in glycemic index units per gram of fiber. Data analysis
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How does PolyGlycopleX (PGX) modulate postprandial glycemia via viscous polysaccharide mechanisms in NCT00801814?
What is the comparative efficacy of PGX versus standard viscous fiber supplements in reducing postprandial hyperglycemia?
Which biomarkers correlate with PGX's glycemic reduction index (GRIP) in healthy subjects consuming solid/liquid meals?
What dose-dependent adverse events are reported for PGX in NCT00801814, and how do they compare to other dietary glucose-lowering agents?
Are there synergistic combination therapies involving PGX and GLP-1 agonists for enhanced postprandial glucose control in metabolic disorders?
Trial Locations
- Locations (1)
Glycemic Index Laboratories, Inc.
🇨🇦Toronto, Ontario, Canada