se of Prebiotic Polydextrose in Periodontitis

Not Applicable

• Conditions: Periodontal Diseases; C07.465.714.533

• Registration Number: RBR-446krjm
• Lead Sponsor: niversidade de São Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-03-04
• Last Update Posted: 29 May 2023
• Study Completion: 2025-03-10

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Presence of at least 15 natural teeth, excluding third molars and teeth indicated for extraction; diagnosis of generalized stage III grade A and B periodontitis, with at least 30% of the teeth with at least one site with probing depth and clinical level of insertion greater than or equal to 5 mm and bleeding on probing.

Exclusion Criteria

Presence of other systemic conditions which can affect the progression of periodontitis or the response to its treatment; long-term administration of anti-inflammatory or immunosuppressive medication; periodontal treatment and / or use of antimicrobials in the last 6 months; use of probiotics in the last 6 months; continuous use of mouthwashes containing antimicrobial agents in the last 6 months; need for prophylactic antibiotic therapy for routine dental procedures; extensive prosthetic rehabilitation; tobacco consumption in the last 5 years; pregnancy and lactation and gastrointestinal diseases.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expected outcome: Reduction in loss of clinical insertion level; assessed by measuring the clinical level of insertion in millimeters, which corresponds to the distance between the cemento-enamel junction and the bottom of the periodontal pocket; considering a variation of at least 15% in the data collected at the beginning and at the end of the study.

Secondary Outcome Measures

Name	Time	Method
Expected outcome 1: Reduction in drilling depth; measured in millimeters from the gingival margin to the bottom of the periodontal pocket; at the beginning and end of the study.